普鲁卡因的抑制性影响血管收缩和钙运动和肠道平滑肌。

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安HY,卡拉奇H

普鲁卡因的抑制性影响血管收缩和钙运动和肠道平滑肌。

Br J杂志。1988年7月,94 (3):789 - 96。doi: 10.1111 / j.1476-5381.1988.tb11590.x。

PubMed ID

3179612 (在PubMed

]

文摘

1。普鲁卡因的影响肌肉紧张和45 ca2 +运动对兔主动脉血管平滑肌和肠平滑肌的绦虫隔绝豚鼠盲肠。2。普鲁卡因(10毫米)诱导猪的收缩,但在主动脉的静息张力的影响不大。3所示。普鲁卡因,0.5 -10毫米,65.4毫米氯化钾诱导的持续收缩放松,10(6)米去甲肾上腺素在主动脉,45.4毫米氯化钾,10 (6)M碳酰胆碱和10 (6)M组胺在猪。普鲁卡因的抑制作用引起高K +全身收缩是由外部Ca2 +的但不是Ca2 +渠道活化剂,湾K 8644年和28392年本金保证产品。4所示。45 ca2 +吸收增加了高K +或去甲肾上腺素在主动脉和高K +或碳酰胆碱的绦虫。的增量被普鲁卡因抑制抑制肌肉收缩所需浓度。 5. In a Ca2+-free solution, noradrenaline and caffeine induced a transient contraction in the aorta, whereas a second application of each stimulant was almost ineffective. Addition of 1-10 mM procaine shortly before the first application of the stimulant inhibited the contraction. After washing the muscle with a Ca2+-free solution without procaine, the second application of the stimulant induced a greater contraction than that in control muscle without procaine pretreatment. 6. Noradrenaline and caffeine released 45Ca2+ from a cellular site in the aorta. Procaine inhibited the effects of these stimulants. 7. It was concluded that procaine may inhibit both the opening of Ca2+ channels and the release of Ca2 + from cellular stores and the former but not the latter effect may be attributable to a local anaesthetic action.

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药物靶点

药物	目标	类	生物	药理作用	行动
普鲁卡因	Calcium-activated钾通道(蛋白质组)	蛋白质组	人类	未知的	拦截器	细节