单剂量口服dexibuprofen [S(+)布洛芬)在成人急性术后疼痛。

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单剂量口服dexibuprofen [S(+)布洛芬)在成人急性术后疼痛。

Cochrane数据库系统启2013年10月23日,(10):CD007550。cd007550.pub3 doi: 10.1002/14651858.。

PubMed ID

24151035 (在PubMed

]

文摘

背景:本文是一个更新之前发表的评论在Cochrane数据库系统评价问题3,2009单剂量口服dexibuprofen (S(+)布洛芬)在成人急性术后疼痛。Dexibuprofen是一种非甾体抗炎药(非甾体抗炎药)许可用于风湿性疾病和其他肌肉骨骼疾病在英国,并在全球其他国家广泛使用。这是一个活跃的布洛芬的异构体。本文试图评估口腔dexibuprofen急性术后疼痛的临床疗效和安全性,使用建立疼痛患者的临床研究,并与测量结果主要是在4到6个小时,使用标准的方法。这种类型的研究已被用于许多几十年建立药物镇痛属性。目的:评估疗效和副作用的单剂量口服dexibuprofen急性术后疼痛,使用许可的方法比较与其他止痛药标准化研究评估使用几乎相同的方法和结果。必威国际app搜索方法:搜索运行在2009年最初的审查和随后的搜索已经运行在2013年8月。我们没有发现任何新发表的研究的结果更新搜索。必威国际app我们寻必威国际app找的随机研究dexibuprofen急性术后疼痛在MEDLINE, EMBASE,和中央(Cochrane图书馆),临床试验报告和发表和未发表的研究从互联网资源的概要。选择标准:随机、双盲、安慰剂对照临床研究口服dexibuprofen成人急性术后疼痛的缓解。数据收集和分析:两个评论作者独立评估研究质量和提取数据。 We extracted pain relief or pain intensity data and converted it into the dichotomous outcome of number of participants with at least 50% pain relief over four to six hours, from which relative risk and number needed to treat to benefit (NNT) were calculated. Numbers of participants using rescue medication over specified time periods, and time to use of rescue medication, were sought as additional measures of efficacy. We collected information on adverse events and withdrawals. MAIN RESULTS: New data were identified for this update in one unpublished trial synopsis (BR1160 1995) in addition to the single study (Dionne 1998) that was included in the original review. In both studies dexibuprofen gave high levels of response, with 51/96 (53%) participants experiencing at least 50% pain relief with dexibuprofen 200 mg and 35/50 (70%) with dexibuprofen 400 mg, compared with 75/147 (51%) with racemic ibuprofen 400 mg, and 12/62 (13%) with placebo. The numbers of participants was too small to calculate NNTs with any meaning. The median time to additional analgesic use was greater than four hours for all active therapies, but about two hours for placebo.Adverse events were generally of mild or moderate intensity and consistent with events normally associated with anaesthesia and surgery. There were no serious adverse events or deaths.Additional data did not alter the conclusions from the earlier review. AUTHORS' CONCLUSIONS: The information from these two studies in acute postoperative pain suggested that dexibuprofen may be a useful analgesic, but at doses not very different from racemic ibuprofen, for which considerably more evidence exists.

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药物

Dexibuprofen