Multiple-dose活性炭在急性自我毒害:随机对照试验。

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M·爱德斯顿,Juszczak E,巴克利NA, Senarathna L,穆罕默德•F艺术观W, Hittarage, Azher年代,Jeganathan K, Jayamanne年代,警长先生,Warrell哒

Multiple-dose活性炭在急性自我毒害:随机对照试验。

柳叶刀》。2008年2月16日,371 (9612):579 - 87。doi: 10.1016 / s0140 - 6736 (08) 60270 - 6。

PubMed ID

18280328 (在PubMed

]

文摘

背景:故意自我毒害的病死率在农村发展中国家10-50-fold高于发达国家,主要原因是使用剧毒农药和植物。因此,我们旨在评估常规治疗是否multiple-dose活性炭,打断enterovascular或肝肠循环,提供好处而没有木炭在这样一个环境中。方法:我们做了一个非盲、平行组,随机,对照试验6个50克剂量的活性炭每隔4 - h和没有木炭和一个50克剂量的活性炭在三个斯里兰卡医院。4632名患者随机接受没有木炭(n = 1554),一个剂量的木炭(n = 1545),或六个剂量的木炭(n = 1533);结果4629例。2338(51%)人摄入农药,而有1647(36%)摄入黄色夹竹桃(Thevetia peruviana)种子。死亡率是主要的结果测量标准。由意图治疗分析。审判和ISRCTN02920054在controlled-trials.com注册。结果:死亡组之间没有差别。 97 (6.3%) of 1531 participants in the multiple-dose group died, compared with 105 (6.8%) of 1554 in the no charcoal group (adjusted odds ratio 0.96, 95% CI 0.70-1.33). No differences were noted for patients who took particular poisons, were severely ill on admission, or who presented early. INTERPRETATION: We cannot recommend the routine use of multiple-dose activated charcoal in rural Asia Pacific; although further studies of early charcoal administration might be useful, effective affordable treatments are urgently needed.

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药物

活性炭