Diacerhein和大黄酸减少冰激IL-1beta和地震活动在人类骨关节炎的软骨。

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摩尔多瓦F, Pelletier JP,班•乔林科尔FC,克劳蒂尔在JM, Martel-Pelletier J

Diacerhein和大黄酸减少冰激IL-1beta和地震活动在人类骨关节炎的软骨。

骨关节炎软骨。2000;8 (3):186 - 96。

PubMed ID

10806046 (在PubMed

]

文摘

摘要目的:IL-1beta在骨关节炎(OA)病理生理学中起着基础性作用和软骨破坏。针对细胞因子的激活机制似乎是重要的治疗方法。随着interleukin-1转换酶(ICE)的生理调制器IL-1beta生产活跃,我们调查的影响diacerhein及其活性代谢物大黄酸治疗OA患者使用,酶表达和合成人类OA软骨。此外,我们看这两种药物的效果在生产的活性形式IL-1beta和地震。方法:冰的表达和合成研究人类OA软骨移植组织利用原位杂交和免疫组织化学方法,分别。药物在冰上OA软骨细胞的影响还取决于Northern和特定的ELISA测定。此外,这两种药物的效果的水平积极IL-1beta和地震被免疫组织化学检查。结果:数据显示,diacerhein和大黄酸没有真正影响减少总冰mRNA Northern分析和原位杂交。显著和显著减少,然而,发现蛋白质产量。ELISA显示减少31% (P < 0.04), diacerhein和大黄酸50% (P < 0.02)。 The drugs' immunohistological cell score reduction was similar to data from the ELISA, and a statistical significant reduction of ICE production was found at both superficial and deep zones of the cartilage. IL-1beta and IL-18 were both preferentially produced in chondrocytes of the superficial zone. For each of these cytokines, both drugs demonstrated a statistically significant decrease in this zone. A marked decrease was also noted in the deep zone, but statistical significance was reached only for rhein. CONCLUSION: These results provide a novel regulatory mechanism by which diacerhein and rhein could exert a down-regulation on IL-1's effect on OA cartilage.

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药物

Diacerein

大黄酸