普鲁士蓝和老鼠铊中毒的防治作用。

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施Meggs WJ, Cahill-Morasco R, RD, Goldfrank LR,霍夫曼RS

普鲁士蓝和老鼠铊中毒的防治作用。

J Toxicol Toxicol。1997; 35 (2): 163 - 6。

PubMed ID

9120885 (在PubMed

]

文摘

背景:铊中毒现在罕见但仍然发生由于杀人的尝试。普鲁士蓝的功效治疗实验已经证明了铊中毒动物模型,及其在人类使用支持坊间数据。由于铊结合巯基组,使用的防治也被认为是作为一个潜在的解药。研究目的:比较普鲁士蓝的功效和铊中毒的小鼠模型中的防治作用。方法:女性瑞士白化小鼠自由获取食物和水。两个研究剂量的铊,皮下注射醋酸铊的无菌水溶解,选择:70毫克/公斤(LD90)和85毫克/公斤(> LD100)。进行了一项随机、安慰剂对照研究与生存在120 h选为测量结果。四个治疗组进行了研究:控制,普鲁士蓝,n -乙酰半胱氨酸常和普鲁士蓝和防治作用。普鲁士蓝是溶解在水中,由口头填喂法的剂量50毫克/公斤。防治作用于生理盐水稀释,给予腹腔注射200毫克/公斤。 Sterile water by gavage and normal saline by peritoneal injection were given as control treatments whenever an active agent was not given. Survival was recorded over a 120 h study period and compared at 120 h by a Fisher's exact test. RESULTS: At 120 h following subcutaneous injection of thallium 70 mg/kg, only 10% of the control animals survived. Treatment with N-acetylcysteine or Prussian blue increased survival to 35% (p = 0.13) and 50% (p = 0.014), respectively. The addition of N-acetylcysteine to Prussian blue offered no benefit over Prussian blue therapy alone. CONCLUSIONS: Prussian blue was found to decrease mortality from thallium poisoning at a dose equal to the LD90 in this model, but not a dose greater than the LD100. No role for N-acetylcysteine in the treatment of thallium poisoning was demonstrated by this study.

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药物

普鲁士蓝