在慢性丙型肝炎α干扰素的副作用。
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Dusheiko G
在慢性丙型肝炎α干扰素的副作用。
肝脏病学。1997年9月26日(3 5 1):112 - 121年代。
- PubMed ID
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9305675 (在PubMed]
- 文摘
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α干扰素已广泛应用治疗慢性丙型肝炎病毒感染。这些包括重组干扰素、纯化天然的白细胞和lymphoblastoid干扰素。α干扰素是由皮下或肌肉注射三次每日或每周的一段6到24个月。一系列广泛的α干扰素的副作用已经描述。一些副作用如发烧、头痛疲劳、关节痛、肌痛是常见的,尤其是在最初的注射。这些早期的干扰素的副作用是可预测的,遇到的大多数病人。这些剂量可能不需要修改,但可以为很大一部分患者是有问题的。其他不良事件的影响可能需要修改甚至减量后2%至10%的患者的治疗。神经副作用如抑郁和烦躁可以最麻烦的;他们的机制并不清楚。 Granulocytes, platelets, and red blood cell counts decrease during treatment, but the decreases are usually mild, although they can be dose limiting if cell counts are low initially. Interferon has important immunomodulatory properties, and treatment can induce autoimmune phenomena, the most frequent being autoimmune thyroiditis with either hypothyroidism or hyperthyroidism, especially in predisposed patients. Other autoimmune disease can be aggravated by interferon therapy. Severe and even life-threatening side effects of interferon occur in 0.1% to 1% of patients; these include thyroid, visual, auditory, renal, and cardiac impairment, and pulmonary interstitial fibrosis. Some of these side effects may be irreversible. Higher doses of interferon (above 5 million units three times weekly) cause higher rates of adverse events than standard doses. Contraindications to alpha interferon have been recognized.
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