androgenic-anabolic类固醇对载脂蛋白、脂蛋白(a)。
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Hartgens F, G Rietjens, Keizer哈,Kuipers H, Wolffenbuttel黑洞
androgenic-anabolic类固醇对载脂蛋白、脂蛋白(a)。
Br J运动。2004年6月,38 (3):253 - 9。
- PubMed ID
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15155420 (在PubMed]
- 文摘
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目的:探讨两种不同方案的androgenic-anabolic类固醇的影响(AAS)的政府对血清脂质和脂蛋白,药物停止和恢复这些变量后,作为心血管疾病的风险的指标在健康男性力量运动员。方法:在一个破盲研究(研究1)血清脂蛋白和脂质在19个受试者评估自我管理经部8到14周,并在16个非美国志愿者。在一个随机,双盲,安慰剂控制的设计、肌内管理的影响诺龙癸酸盐(200毫克/周)进行为期八周在同一变量在16个健美运动员进行了研究(研究2)。空腹血清总胆固醇浓度,甘油三酯脂蛋白胆固醇(高密度脂蛋白胆固醇),HDL2-cholesterol (HDL2-C) HDL3-cholesterol (HDL3-C)、载脂蛋白A1 (Apo-A1)、载脂蛋白B (Apo-B)和脂蛋白(a) (Lp (a))测定。结果:在研究1 AAS管理导致血清高密度脂蛋白胆固醇浓度降低(从1.08(0.30)到0.43(0.22)更易/ l), HDL2-C(从0.21(0.18)到0.05(0.03)更易/ l), HDL3-C(从0.87到0.40(0.24)(0.20)更易与l和Apo-A1(从1.41(0.27)到0.71 (0.34)g / l),而Apo-B增加从0.96 (0.13)1.32 (0.28)g / l。血清Lp (a)从189年下降(315)32 (63)U / l。总胆固醇和甘油三酯没有显著变化。改变AAS管理8到14周后具有可比性。任何改变发生在控制。AAS戒烟六周后,血清高密度脂蛋白胆固醇,HDL2-C, Apo-A1, Apo-B, Lp (a)仍未回到基线浓度。14周与AAS管理复苏放缓预处理浓度比政府为8周。 In study 2, nandrolone decanoate did not influence serum triglycerides, total cholesterol, HDL-C, HDL2-C, HDL3-C, Apo-A1, and Apo-B concentrations after four and eight weeks of intervention, nor six weeks after withdrawal. However, Lp(a) concentrations decreased significantly from 103 (68) to 65 (44) U/l in the nandrolone decanoate group, and in the placebo group a smaller reduction from 245 (245) to 201 (194) U/l was observed. Six weeks after the intervention period, Lp(a) concentrations had returned to baseline values in both groups. CONCLUSIONS: Self administration of several AASs simultaneously for eight or 14 weeks produces comparable profound unfavourable effects on lipids and lipoproteins, leading to an increased atherogenic lipid profile, despite a beneficial effect on Lp(a) concentration. The changes persist after AAS withdrawal, and normalisation depends on the duration of the drug abuse. Eight weeks of administration of nandrolone decanoate does not affect lipid and lipoprotein concentrations, although it may selectively reduce Lp(a) concentrations. The effect of this on atherogenesis remains to be established.
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