Mangafodipir三钠(MnDPDP)之二肝脏和胰腺的磁共振成像。

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Mangafodipir三钠(MnDPDP)之二肝脏和胰腺的磁共振成像。

Acta Radiol增刊。1998;415:1-31。

PubMed ID

9571956 (在PubMed

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文摘

对比增强磁共振成像(MRI)的肝脏和胰腺经常执行改善这些器官病变检测的敏感性和特异性。使用组织的概念对比媒体选择性地增强正常的薄壁组织,但不损伤,所以肿瘤与正常组织之间的反差增加,和损伤检测能力提高。Mangafodipir三钠(MnDPDP)已经被开发成一个hepatocellular-specific造影剂,但吸收也被发现在胰腺组织。在这项研究的安全性和诊断有效性MnDPDP研究在健康志愿者和患者的肝脏和胰腺肿瘤。在健康志愿者(n = 8),存在剂量依赖的相关性增强t1影像观察在正常肝脏和胰腺实质灌注后MnDPDP剂量的5和10 mumol /公斤。最大增强两个剂量组是77和110%在肝脏,胰腺和57个和84%,分别。enhancement-over-time档案证明有效成像窗口对肝脏2 h,并为胰腺/ 4 h。没有可衡量的增强大脑结构完整的血脑屏障,保护和没有变化的临床重要性被发现在生命体征或血液和尿化学变量。与unenhanced图像(包括t2影像)相比,在MnDPDP-enhanced发现了更多病变T1影像82年肝肿瘤患者(主要是转移)。特征,如边缘增强和肝细胞癌的增强可以为鉴别诊断提供信息。 In a study on patients with pancreatic tumors, mainly adenocarcinomas (n = 21) and islet cell tumors (n = 19), two additional lesions were found in the MnDPDP-enhanced images. The contrast enhancement in the pancreatic parenchyma can vary greatly, depending on the site of the enhancing part of the organ in relation to a large tumor. The tumors of both origins were also enhanced post-contrast, but to a lesser degree than the normal pancreatic tissue. MnDPDP enhancement was investigated in 30 liver metastases from endocrine tumors in 13 patients. These lesions showed a signal increase of about 49% post-contrast, which lasted longer than that in the normal liver tissue. The findings may help to distinguish these tumors from other metastatic tumors. T1-weighted sequences of four types, including a spin-echo and three variants of fast gradient-echo sequences, and various parameter combinations, were investigated in healthy volunteers (n = 6), with the aim of finding the optimal sequence for MnDPDP-enhanced MRI of the liver and pancreas. The fat-and-water out-of-phase, fast field (gradient)-echo sequence was the best for imaging of both the liver and pancreas. The studies have shown that MnDPDP is safe when given as an infusion, and is effective as a liver- and pancreas-specific contrast medium, with improved lesion detection in MRI of these organs. It is also useful for the characterization of liver tumors.

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Mangafodipir