药物动力学和indapamide临床药理学。
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卡鲁索FS, Szabadi RR Vukovich RA
药物动力学和indapamide临床药理学。
我的心j . 1983年7月;106 (1 Pt 2): 212 - 20。0002 - 8703 . doi: 10.1016 / (83) 90119 - 9。
- PubMed ID
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6869203 (在PubMed]
- 文摘
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Indapamide是一个新的降压利尿代理表示治疗高血压和水肿。Indapamide显示血管反应性的改变钙和其它受体激动剂,建议直接血管效应的可能性。药物推荐剂量的2.5到5毫克每天一次。迅速和完全从胃肠道吸收,导致最大的血液水平大约2.3小时。共同服用indapamide的食物或抗酸药并不减少生物利用度。血药浓度的线性比例随着剂量增加以下一个或多个剂量也很明显。其他药代动力学参数不是剂量相关。Indapamide体内广泛分布着广泛的红细胞。与血浆蛋白结合大约是76%。消失的indapamide从血液中两相的,终端半衰期约为16小时。 Renal clearance represents less than 10% of the total systemic clearance of the parent drug, showing the dominant role of hepatic clearance. Studies of 14C-labeled indapamide in humans demonstrate that 70% of the radioactivity is excreted in urine and 23% in feces. Indapamide is extensively metabolized; less than 7% of the dose is excreted in urine as unchanged compound. Studies of patients with renal impairment showed little or no accumulation of indapamide in the blood in comparison to patients with normal renal function. Clinical studies demonstrate that indapamide has diuretic properties. Free water clearance studies indicate a site of action in the cortical diluting segment of the distal tubules. No adverse effect of indapamide on renal function is evident in normal volunteers, hypertensive patients, or geriatric hypertensive patients, as determined by glomerular filtration rate or effective renal plasma flow. Hemodynamic studies of indapamide in patients with mild to moderate hypertension show a significant (p less than 0.05) decrease in mean blood pressure (16%) and total peripheral resistance (15%). No other significant hemodynamic effects are evident. The data suggest that indapamide may produce antihypertensive activity through a dual mechanism of action--diuretic and direct vascular. Additionally, it appears to be safe even for patients with impaired renal function.
DrugBank数据引用了这篇文章
- 药物
- 药物反应
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反应 细节 - 食物相互作用
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药物 交互 Indapamide 有或没有食物。
