最终报告的安全评估EDTA、EDTA二钠钙、联胺EDTA, EDTA钾、EDTA二钠,TEA-EDTA,四钠EDTA, tripotassium EDTA,三钠的EDTA, HEDTA, HEDTA三钠。

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lanign RS, Yamarik助教

最终报告的安全评估EDTA、EDTA二钠钙、联胺EDTA, EDTA钾、EDTA二钠,TEA-EDTA,四钠EDTA, tripotassium EDTA,三钠的EDTA, HEDTA, HEDTA三钠。

Int J Toxicol。2002; 21增刊2:95 - 142。doi: 10.1080 / 10915810290096522。

PubMed ID
12396676 (在PubMed
]
文摘

EDTA(乙二胺四乙酸)及其盐是二元胺代替。HEDTA(羟乙基乙二胺triacetic酸)及其三钠取代胺。这些成分作为螯合剂在化妆品配方中。典型的使用EDTA的浓度小于2%,与其他盐在当前使用更低的浓度。最低剂量报告导致动物毒性作用是750毫克/公斤/天。这些螯合剂是细胞毒性和弱基因毒性,但不会致癌。口腔暴露EDTA产生不良动物的生殖和发育的影响。临床试验报告没有通过皮肤吸收EDTA的盐。然而,这些成分可能会影响其他化学物质的通道进入皮肤,因为他们将螯合钙。暴露于EDTA在大多数化妆品配方,因此,会产生系统性暴露水平远低于在口服给药毒性研究。 Exposure to EDTA in cosmetic formulations that may be inhaled, however, was a concern. An exposure assessment done using conservative assumptions predicted that the maximum EDTA dose via inhalation of an aerosolized cosmetic formulation is below that shown to produce reproductive or developmental toxicity. Because of the potential to increase the penetration of other chemicals, formulators should continue to be aware of this when combining these ingredients with ingredients that previously have been determined to be safe, primarily because they were not significantly absorbed. Based on the available data, the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations.

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