比较的影响局部levobunolol和timolol人类眼表面的解决方案。

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横井Ishibashi T, N,木下光男

比较的影响局部levobunolol和timolol人类眼表面的解决方案。

角膜。2003年11月,22(8):709 - 15所示。

PubMed ID

14576520 (在PubMed

]

文摘

目的:比较盐酸levobunolol和马来酸timolol撕裂的影响体积,precorneal泪膜稳定,角膜上皮屏障功能正常的人类的眼睛。对象和方法:研究人口由14名健康志愿者。获得预处理基线值,我们确定的半径由meniscometry撕裂半月板(RTM);无创性分手时间(NIBUT)以泪precorneal泪膜镜面显微镜;用荧光光度计和角膜荧光素吸收。Levobunolol盐酸(0.5%)或timolol马来酸溶液(0.5%)被连续4周每天两次灌输进1眼;侧眼与其他局部治疗药物每天两次。在研究结束的时期,相同的测试被执行,预处理和后处理结果比较。结果:Timolol解决方案,和levobunolol没有显著减少NIBUT从基线值。RTM显著减少了治疗timolol或levobunolol解决方案。 Corneal fluorescein uptake was not significantly changed, although it was higher after treatment with both topical drugs. CONCLUSIONS: Four-week treatment with timolol solution resulted in significant instability of the precorneal tear film. Both timolol and levobunolol solution significantly decreased tear volume on the ocular surface. These results indicate that levobunolol solution applied twice daily has equal effects on the tear volume and corneal epithelial barrier function as does timolol solution applied twice daily and that it affects precorneal tear film stability less than timolol solution.

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药物

Levobunolol