人类脐带血单核细胞治疗急性心肌梗塞。

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亨宁RJ,阿布·阿里H,巴JU,摩根MB, AE, Sanberg公关

人类脐带血单核细胞治疗急性心肌梗塞。

细胞移植。2004;13 (7 - 8):729 - 39。doi: 10.3727 / 000000004783983477。

PubMed ID
15690974 (在PubMed
]
文摘

细胞移植是一种新的治疗方法,用于改善心脏功能在心脏受损的心肌梗塞。我们已经调查了使用人类脐带血单核细胞的祖细胞(HUCBC)治疗急性心肌梗死。对照组由24正常老鼠没有干预。梗死+汽车集团由33个老鼠接受了冠状动脉左前降枝(小伙子)结扎和1 h后Isolyte边境的梗塞。梗死+ HUCBC集团由38个老鼠接受小伙子结扎和1 h后10 (6)HUCBC Isolyte直接进入梗死边界。免疫抑制没有给任何老鼠。测量左心室(LV)射血分数,LV的压力,dP / dt,和梗塞大小测定在基线和1,2,3,4个月。控制的射血分数减少从88 + / - -3%在4个月78 + / - -4% (p = 0.03)的正常老化。梗死后梗死+汽车集团,射血分数降低了51从87 + / - -4%到+ / - -3%之间1和4个月(p < 0.01)。相比之下,梗塞的+ HUCBC-treated老鼠心脏的射血分数从87 + / - -4%减少到1个月63 + / - -3%,但逐渐增加到69 + / - -6%在3和4个月,这是不同于梗死+车辆组大鼠(p < 0.02),但类似于控制。 At 4 months, anteroseptal wall thickening in infarct + HUCBC group was 57.9+/-11.6%, which was nearly identical to the control anteroseptal thickening of 59.2+/-8.9%, but was significantly greater than the infarct + vehicle group, which was 27.8+/-7% (p < 0.02). dP/dt(max) increased by 130% in controls with 5.0 microg of phenylephrine (PE)/min (p < 0.001). In the infarct + vehicle group, dP/dt(max) increased by 91% with PE (p = 0.01). In contrast, in the infarct + HUCBC group, dP/dt(max) increased with PE by 182% (p < 0.001), which was significantly greater than the increase in dP/dt(max) in the infarct + vehicle group (p = 0.03) and similar to the increase in the controls. Infarct sizes in the infarct + HUCBC group were smaller than the infarct + vehicle group and averaged 3.0+/-2.8% for the infarct + HUCBC group versus 22.1+/-5.6% for infarct + vehicle group at 3 months (p < 0.01); at 4 months they averaged 9.2+/-2.0% for infarct + HUCBC group versus 40.0+/-9.2% for the infarct + vehicle group (p < 0.001). The present experiments demonstrate that HUCBC substantially reduce infarction size in rats without requirements for immunosuppression. As a consequence, LV function measurements, determined by LV ejection fraction, wall thickening, and dP/dt, are significantly greater than the same measurements in rats with untreated infarctions.

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