Oleoylethanolamide补充减少炎症和氧化应激在肥胖的人:一个临床试验。
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Payahoo L, Khajebishak Y, Asghari Jafarabadi M, Ostadrahimi
Oleoylethanolamide补充减少炎症和氧化应激在肥胖的人:一个临床试验。
阿德制药公牛。2018年8月,8 (3):479 - 487。doi: 10.15171 / apb.2018.056。Epub 2018年8月29日。
- PubMed ID
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30276145 (在PubMed]
- 文摘
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目的:肥胖是一个严重的公共卫生问题在世界范围内,导致许多慢性病的发病率。肥胖被认为是一种慢性低度炎症疾病。神经系统改变语气也参与肥胖的发病机制。本研究旨在探讨oleoylethanolamide补充对炎症生物标记物和氧化应激的影响肥胖的人。方法:随机、双盲、安慰剂对照的临床试验进行了2016年的60名健康的肥胖的人在大不里士,伊朗。合格的受试者被随机分为干预(收到日报》两个125毫克OEA胶囊)和对照组(此句的大量淀粉),治疗8周。(5毫升)的血液标本在禁食状态基线和末端的研究。MDA的含量和助教使用分光光度计测量。高sensitive-C反应蛋白水平是衡量Immunoturbidimetry化验使用商业套装。il - 6和tnf水平化验的ELISA方法。 The differences between groups were assessed by ANCOVA and statistical significance was determined at p<0.05. Results: Analysis was done on 56 participants who continued intervention until the end of the study. A significant decrease in the IL-6 and TNF-alpha serum concentrations was observed in the intervention group (p<0.001). Changes in other variables were undetectable (p>0.05). Conclusion: The use of OEA as a complementary pharmacotherapy agent could be effective in improving inflammation and oxidative stress in obese people. Future studies are needed to confirm the obtained results.
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