β1受体
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β1受体
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- PubMed ID
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30422499 (在PubMed]
- 文摘
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beta 1受体,连同beta 2、alpha -和α2受体,肾上腺素能受体主要负责信号的交感神经系统。Beta-agonists绑定到β受体在不同的人体组织。beta 1受体主要是发现在三个位置:心脏、肾脏和脂肪细胞。的beta 1肾上腺素能受体是通过Gs G-protein-coupled受体沟通的α亚基。通过信号Gs, cAMP-dependent通过腺苷酸环化酶途径启动,这导致受体的功能的增强作用。有针对性的beta 1受体的激活增加心脏窦房结(SA)节点,房室(AV)节点,和心室肌发射,从而增加心率和收缩性。通过这两个值增加,体积中风和心脏输出也将增加。这显然效果显示心脏的输出方程。心输出量等于中风的产品体积和心率。中风体积或心率增加,这两个beta 1受体的靶向激活将会增加,心输出量会增加,从而增加灌注组织整个身体。 In the kidney, smooth muscle cells in the juxtaglomerular apparatus contract and release renin. This cascading effect will eventually increase blood volume through the actions of angiotensin II and aldosterone. In the adipocyte[1], the beta-1 receptor is targeted to upregulate lipolysis. Various hormones may target the adrenoreceptors with different affinities. In this article, we will focus on the beta receptors, in particular, beta-1 adrenergic receptors. The chemicals epinephrine, dopamine, and isoproterenol[2] target beta-1 and beta-2 receptors almost equally. Norepinephrine and dobutamine target beta-1 to a greater degree than beta-2. While hormones are the normal pathway by which these systems typically activate, they can also be activated or blocked medically through a multitude of pharmacologic therapies, some of which will be discussed below.
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