(bis) - p-hydroxyphenyl -pyridyl-2-methane (BHPM)——活性代谢物的泻药bisacodyl和钠picosulfate-enhances收缩性和人类肠体外分泌。
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泽勒杰伊汉克鲁格D, Demir即走,F, Schemann M
(bis) - p-hydroxyphenyl -pyridyl-2-methane (BHPM)——活性代谢物的泻药bisacodyl和钠picosulfate-enhances收缩性和人类肠体外分泌。
Neurogastroenterol Motil。2018年7月,30 (7):e13311。doi: 10.1111 / nmo.13311。Epub 2018年2月14。
- PubMed ID
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29441646 (在PubMed]
- 文摘
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背景:刺激性泻药被广泛用于治疗便秘。我们研究人类肠道准备小型和大型的影响双(p-hydroxyphenyl) -pyridyl-2-methane (BHPM)的活性代谢物泻药bisacodyl和钠picosulfate光滑肌肉张力和上皮分泌。方法:圆形和小型或大型纵向肌肉的肠道准备记录与等距力传感器。上皮离子通量(ISC)和美国商会组织电阻测量技术在顶端和基底BHPM应用到大型肠道黏膜、黏膜下层的准备。研究在宏观上进行正常的79例患者的标本。主要结果:BHPM concentration-dependently(0.5 - 5妈妈)增加循环的语气和纵肌从小型到大肠。效果在大小肠纵行肌和最小的最强小肠循环肌肉。增加肌肉张力阻止了l型钙通道阻滞剂硝苯地平(+ +)但神经阻滞剂河豚毒素不敏感。基底顶端或BHPM concentration-dependently ISC减少或增加,分别。王者文化1.1 (BK)通道阻滞剂iberiotoxin逆转顶端ISC减少而河豚毒素基底逆转ISC增加。 BHPM had no effect on tissue resistance or nerve-mediated secretory or muscle response with one exception: at the highest concentration basolateral BHPM reduced nerve-mediated secretion. CONCLUSIONS AND INTERFERENCES: BHPM enhanced mucosal secretion and muscle contractility. Results suggested that the laxative effect of BHPM was a consequence of the increase in muscle tone as well as an increased K(+) secretion when acting luminally and a nerve-driven Cl(-) and HCO3(-) secretion once acting basolaterally after absorption.
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