免疫治疗的方法来减少COVID-19。

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Owji H, Negahdaripour M, Hajighahramani N

免疫治疗的方法来减少COVID-19。

Int Immunopharmacol。2020年11月,88:106924。doi: 10.1016 / j.intimp.2020.106924。Epub 2020年8月21日。

PubMed ID

32877828 (在PubMed

]

文摘

COVID-19,最近引发的疾病出现严重急性呼吸系统综合症冠状病毒2 (SARS-CoV-2),实施了不可预知的世界的负担。药物再利用用来迅速找到治愈;尽管努力,目前还没有药物或疫苗治疗或预防COVID-19。除了抗病毒药物,免疫治疗策略建议考虑免疫反应作为东道主的角色防御病毒,以及SARS-CoV-2抑制干扰素诱导的免疫逃避策略。主动免疫通过疫苗、干扰素管理被动免疫治疗康复的等离子体或合成单克隆和多克隆抗体,以及免疫调节药物,不同的免疫治疗方法,将本文中提到的。重点将是被动免疫治疗干预措施。干扰素可能是有用的在某些阶段。疫苗的发展一直遵循以前所未有的速度。这些疫苗已进入人体临床试验。康复的血浆疗法已经在许多国家帮助拯救生命的重症患者。 Different antibodies that target various steps of SARS-CoV-2 pathogenesis or the associated immune responses are also proposed. For treating the cytokine storm induced at a late stage of the disease in some patients, immune modulation through JAK inhibitors, corticosteroids, and some other cognate classes are evaluated. Given the changing pattern of cytokine induction and immune responses throughout the COVID-19 disease course, different adapted approaches are needed to help patients. Gaining more knowledge about the detailed pathogenesis of SARS-CoV-2, its interplay with the immune system, and viral-mediated responses are crucial to identify efficient preventive and therapeutic approaches. A systemic approach seems essential in this regard.

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药物

Sotrovimab