口服补充镁对血压、血小板聚集和钙处理在醋酸去氧皮质酮诱导高血压大鼠。

文章的细节

引用

复制到剪贴板

Kh R, Khullar M,卡米,Pandhi P, Uppal R

口服补充镁对血压、血小板聚集和钙处理在醋酸去氧皮质酮诱导高血压大鼠。

J Hypertens。2000年7月,18(7):919 - 26所示。

PubMed ID

10930190 (在PubMed

]

文摘

目的:研究口服补充镁对血压的影响,血小板聚集和血小板钙处理在醋酸去氧皮质酮(DOCA)全身高血压大鼠。设计和方法:老鼠被分成四组,每组20。药物治疗有六周时间。控制老鼠的车辆。DOCA在第二组,15毫克/公斤,每周两次皮下注射1%的生理盐水代替饮用水。第三组是氧化镁(分别),每天1克/公斤,口头填喂法。第四组是分别以DOCA和1%氯化钠。每周测量血压和心率。血小板聚集,胞内钙,钙和钙吸收射流研究第六周结束时执行。血清镁浓度,血浆水平的活性氮中间体(RNI)和瓜氨酸也测量结果:有一个DOCA-treated老鼠血压显著升高。 Magnesium prevented the gradual rise in blood pressure when given along with DOCA, but had no effect in normotensive rats. Heart rate did not show any significant change. Platelet aggregation was significantly reduced in all the treatment groups compared to the control group. DOCA treatment produced a significant increase in the intracellular calcium concentration as well as the calcium uptake compared to the control group. Magnesium supplementation inhibited the increased intracellular calcium concentration and calcium uptake in DOCA-treated rats. RNI and citrulline levels were elevated in all the treatment groups. Serum magnesium levels were significantly higher in the magnesium-treated and DOCA plus magnesium-treated rats. CONCLUSIONS: Magnesium supplementation prevents blood pressure elevation in DOCA hypertensive rats. These effects are associated with inhibition of platelet calcium uptake and decreased intracellular free calcium concentration.

DrugBank数据引用了这篇文章

药物

氧化镁

醋酸镁四水合物