99年评估mtc-succimer儿科患者的剂量。

文章的细节

引用

复制到剪贴板

加尔布雷斯W,阮,哈里森DL,陈X, Talley K

99年评估mtc-succimer儿科患者的剂量。

J诊断地中海抛光工艺。2013年6月,41 (2):81 - 4。doi: 10.2967 / jnmt.112.118836。Epub 2013年4月22日。

PubMed ID

23608072 (在PubMed

]

文摘

未标记的:平衡图像质量和辐射剂量是一个目标,每一个诊断过程要求辐射。我们机构相比(99米)的剂量Tc-labeled succimer,通常被称为dimercaptosuccinic酸((99)Tc-DMSA),儿科患者使用2的计算方法,身体表面积(BSA的方法我们使用从2009年到2010年)和体重(BW, 2011年我们使用的方法)。方法:回顾性研究230个床位住院,三级护理学术儿科医院获得客观数据17岁以下的病人y接受肾核医学过程(99)Tc-DMSA使用并行图像和4 150000 - 300000 -计数统计针孔图像。数据收集包括病人年龄、性别、身高、体重,计算活动,化验活动、管理活动,剩余注射器活动,成像时间,明显的病人或设备过程影响因素。结果:计算活动基于BSA高于基于BW的计算活动。(99米)Tc-DMSA吸附塑料注射器是重要的,3% - -82%的范围。由于吸附,平均23.7兆贝可(SD, + / -31兆贝可)添加到病人的剂量计算时的顺序。因此,化验活动是在两组明显高于计算活动。管理活动的相关性BSA和BW计算分别为0.75和0.83,分别。管理活动从BSA和BW组外的美国大学放射学(ACR)推荐指南的59%和45%,分别。 Overall, children less than 2 y old were above the ACR recommendations 80% of the time. There was a poor correlation between administered activity and total imaging time (r = 0.23). Average imaging time overall for 5 planar views was 14.8 min (+/-7.1 min). Patients receiving less than the ACR-recommended administered activities (<1.85 MBq/kg) had an average increase in imaging time of 4.5 min (+/-3.4 min). CONCLUSION: The activity administered to patients was significantly affected by the amount of (99m)Tc-DMSA activity adsorbed to the syringe. Syringe residual should be considered when standardizing (99m)Tc-DMSA imaging protocols and calculating patient dose. Although (99m)Tc-DMSA adsorption was variable, the administered activities correlated with calculated activities. In all but one of our patients, the total imaging time was far less than recommended by the ACR and European Association of Nuclear Medicine guidelines. The study indicates that using the BW calculation of 3.7 MBq/kg resulted in a range of administered activity of 1.85-2.59 MBq/kg. (99m)Tc-DMSA dosing of 3.7 MBq/kg for pinhole imaging should be appropriate for most studies.

DrugBank数据引用了这篇文章

药物

锝tc - 99 m succimer