肝脏疾病与职业暴露于溶剂二甲基甲酰胺。

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Redlich CA,贝克特WS,节省的J,巴维克千瓦,rie CA,米勒H, Sigal SL, Shalat SL,卡伦先生

肝脏疾病与职业暴露于溶剂二甲基甲酰胺。

108年5月,安实习生地中海。1988 (5):680 - 6。

PubMed ID

3358569 (在PubMed

]

文摘

研究目的:描述肝脏疾病的爆发在织物涂料工厂工人;并确定疫情的原因和自然历史和战略为临床识别、治疗和预防。设计:clinical-epidemiological调查。设置:学术医学中心、职业医学诊所,和工地。病人:58六十六工人参与了这项研究。至少都有标准肝功能测试一次。46个工人完成一份调查问卷;27更广泛的临床评价了公认的肝功能异常。结果:整厂肝脏疾病爆发后被公认的新员工提出了肝炎的症状和体征。评估现场显示,二甲基甲酰胺,一种广泛使用的工业溶剂和已知的肝毒素,被用于涂层织物在通风的地方没有适当的皮肤保护。 No other major hepatotoxic exposure was identified. Overall, 36 of 58 (62%) workers tested had elevations of either aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels. Enzyme abnormalities occurred almost exclusively in production workers (35 of 46 were abnormal), whereas only 1 of 12 nonproduction workers showed any elevations in enzyme levels (P less than 0.0001). Serologic tests excluded known infectious causes of hepatitis in all but 2 workers and changes characteristic of toxic liver injury were confirmed by histologic examinations of biopsy specimens from 4 workers. The ratio of AST to ALT levels was one or less in all but 1 worker. After modification of work practices and removal of workers most severely affected from exposure, improvement in liver enzyme abnormalities and symptoms in most patients were seen, although some patients showed persistent elevations of enzyme levels. CONCLUSIONS: an outbreak of toxic liver disease has been associated with exposure to dimethylformamide in the workplace. The diagnosis of toxic liver disease was established by the clinical histories, negative viral serologies, an enzyme pattern of ALT levels being greater than AST levels, epidemiologic data on coworkers, and liver biopsy specimens. The high prevalence of unsuspected liver enzyme abnormalities in these workers suggests that occupational liver disease may occur more frequently than is generally recognized.

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药物

N, N-dimethylformamide