镇痛药物的滥用的流行病学研究。非那西汀和水杨酸对死亡率和心血管发病率的影响(1968 - 1987)

文章的细节

引用

复制到剪贴板

Dubach UC, Rosner B,斯特姆苹果T

镇痛药物的滥用的流行病学研究。非那西汀和水杨酸对死亡率和心血管发病率的影响(1968 - 1987)

郑传经地中海J。1991年1月17日,324 (3):155 - 60。

PubMed ID

1984193 (在PubMed

]

文摘

背景:非那西汀滥用是产生肾脏疾病;水杨酸使用应该预防心血管疾病。我们进行了一项前瞻性纵向流行病学研究调查的影响这些药物对死因别死亡率和心血管发病率。方法:在1968年,我们评价一个研究小组的623名健康女性30至49岁经常摄入非那西汀的证据,以尿代谢物的排泄,和一个匹配的对照组621名女性。水杨酸排泄也测量。所有受试者进行了20年。结果:生命表分析死亡的20年期间,调整出生年份,吸烟,和后续的长度,显示组总体死亡率之间的显著差异(研究组与对照组,74与27人死亡;相对风险,2.2;95%置信区间,1.5至3.3),由于泌尿道的死亡或肾脏疾病(相对风险:16.1;95%置信区间,3.9至66.1),因癌症死亡人数(相对风险,1.9; 95 percent confidence interval, 1.1 to 3.3), and deaths due to cardiovascular disease (relative risk, 2.9; 95 percent confidence interval, 1.5 to 5.5). The relative risk of cardiovascular disease (fatal or nonfatal myocardial infarction, heart failure, or stroke) was 1.8, and the 95 percent confidence interval 1.3 to 2.6. The odds ratio for the incidence of hypertension was 1.6, and the 95 percent confidence interval 1.2 to 2.1. The effects of phenacetin on morbidity and mortality, with adjustment for base-line salicylate excretion, were similar. In contrast, salicylate use had no effect on either mortality or morbidity. CONCLUSIONS: Regular use of analgesic drugs containing phenacetin is associated with an increased risk of hypertension and mortality and morbidity due to cardiovascular disease, as well as an increased risk of mortality due to cancer and urologic or renal disease. The use of salicylates carries no such risk.

DrugBank数据引用了这篇文章

药物

非那西汀