锌羟基吡啶硫酮:局部抗菌与复杂的配药学。

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施瓦兹小

锌羟基吡啶硫酮:局部抗菌与复杂的配药学。

J药物2月杂志。2016;15 (2):140 - 4。

PubMed ID

26885780 (在PubMed

]

文摘

锌羟基吡啶硫酮(ZPT)是一种活性物质,已被用于50多年来有效地治疗头皮屑和脂溢性皮炎(D / SD)。它已成为最常见的材料,它的使用已经扩大到包括其他好处,如皮肤卫生。然而,有很多关于ZPT赏识。这是一个合理开发分子是仿照天然抗菌曲霉酸。其抗真菌活性的分子基础已被阐明。的功效ZPT来源于两个属性。首先,它有一个非常广泛的抗菌谱的活动,包括真菌、革兰氏阳性和阴性细菌。第二,该材料具有非常低的溶解度,导致配方和交付颗粒材料,具有明显的性能优势。粒子的沉积和留存在目标即使从皮肤表面冲洗干净产品。这些粒子缓慢释放分子活性物质与真菌和细菌细胞表面相互作用来控制人口,缓释水库提供扩展功能和持久效益。 This particulate nature, though, results in complex pharmaceutics to realize the full efficacy benefits; it is common to see products with the same ZPT level having widely varying levels of clinical performance. Several product matrix-determined factors directly impact resultant benefits: ZPT must be retained on the skin surface achieving uniform spatial distribution laterally as well as within hair follicles (especially on scalp); ZPT must be maintained as a physically stable dispersion in product; ZPT must be maintained in a chemically active form as there are many chemical reactions that can occur that can harm ZPT bioactivity. The benefits achievable by employing ZPT require significant pharmaceutics expertise to realize the full benefits of this active material.

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药物

羟基吡啶硫酮