心血管的影响enoximone在异氟烷麻醉小马。

文章的细节

引用

复制到剪贴板

Schauvliege年代,Van den Eede, Duchateau L, Gasthuys F

心血管的影响enoximone在异氟烷麻醉小马。

兽医Anaesth。2007年11月,34 (6):416 - 30。Epub 2007年8月13日。

PubMed ID

17696974 (在PubMed

]

文摘

目的:Enoximone三磷酸二酯酶抑制剂常用改善心输出量(CO)的人。使用enoximone尚未报道的马,这inodilator检查的影响在异氟烷麻醉矮种马。研究设计:前瞻性随机试验研究。动物:六个健康的小马,重286(212 - 367)+ / - 52公斤,5.0 + / - 1.6岁(4 - 6.5)。方法:用romifidine镇静后[80 microg公斤(1)静脉注射(IV)],全身麻醉诱导与咪达唑仑(0.06毫克公斤(1)IV)和氯胺酮(2.2毫克公斤(1)IV)和维护与异氟烷氧(Et Iso 1.7%)。小马是通风保持eucapnia(帕科(2)4.66 - -6.00 kPa)。每个小马麻醉两次,间隔3周;接收enoximone 0.5毫克公斤(1)IV (E)或生理盐水post-induction (S) 90分钟。心率(HR)、动脉(美联社)和右心房压力(RAP)测定治疗前,每5分钟之间T0(治疗),直到T120 T30然后每10分钟。心输出量测量(锂稀释技术)和血气分析(动脉和中央静脉样本)之前执行T0 T5, T10, T20, T40, T60 T80, T100 T120。 Stroke volume (SV), systemic vascular resistance (SVR), venous admixture (Qs/Qt) and oxygen delivery (DO(2)) were calculated. RESULTS: Enoximone induced significant increases in HR, CO, SV, Qs/Qt and DO(2) and a significant decrease in RAP. No significant differences were detected for AP, SVR and blood gases. No cardiac arrhythmias or other side effects were observed. CONCLUSIONS AND CLINICAL RELEVANCE: The present results suggest that in isoflurane anaesthetized ponies, enoximone has beneficial effects on CO and SV without producing significant changes in blood pressure. Despite an increase in Qs/Qt, DO(2) to the tissues was improved.

DrugBank数据引用了这篇文章

药物

Enoximone