Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

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Hagmann WK, Caldwell CG, Chen P, Durette PL, Esser CK, Lanza TJ, Kopka IE, Guthikonda R, Shah SK, MacCoss M, Chabin RM, Fletcher D, Grant SK, Green BG, Humes JL, Kelly TM, Luell S, Meurer R, Moore V, Pacholok SG, Pavia T, Williams HR, Wong KK

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8.

PubMed ID

10987430 [View in PubMed

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Abstract

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Pimagedine	Nitric oxide synthase, inducible	IC 50 (nM)	101000	N/A	N/A	Details