人类的犁鼻系统。

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Monti-Bloch L, C Jennings-White, Dolberg DS,柏林DL

人类的犁鼻系统。

心理神经内分泌学。1994;19 (5 - 7):673 - 86。

PubMed ID

7938363 (在PubMed

]

文摘

我们研究了犁鼻系统的功能特征在临床正常成年男女(年龄20-45)的主题。化学感觉的物质管理在连续点状的脉冲气流从一个多功能miniprobe,含有一个非极化电极。负电位与受体的特征电位记录从表面的犁鼻器(VNO)和嗅觉上皮(OE)为了应对某些物质在这里定义为vomeropherins(见定义的介绍主要文本)和olfactants。刺激VNO与当地femtomole大量vomeropherins产生去极化与受体的特征的潜力。相同的物质只有一小OE的响应,并从鼻腔呼吸道粘膜没有响应。三个vomeropherins PH15、PH78 PH84特别好被大多数男性受试者的VNO (p < . 01;n = 30)。物质PH30, PH56 PH94B,产生了类似的效果在大多数女性受试者的VNO (p < . 01;n = 30)。应对几乎所有vomeropherins展出两性异形。 Stimulation of the OE with the same quantity of odorants 1,8-cineole and l-carvone produced depolarization of 6.8 +/- 2.6 mV, but little or no response in the VNO. Therefore, the human VNO seems to have a unique specificity for certain chemosensory substances when compared to the OE. Administration of PH15 and PH78 to the VNO of male subjects (but not to female subjects) significantly increased electrodermal activity (p < .02) and skin temperature (p < .01). On the other hand, administration of PH84 to the VNO of male subjects decreased skin temperature but had little effect on electrodermal activity. Autonomic changes were accompanied by an increased percentage of alpha-cortical activity for all three vomeropherins. In female subjects (but not in male subjects) vomeropherins PH56 and PH94B significantly increased electrodermal activity (p < .01), skin temperature (p < .01), and alpha-cortical activity (p < .01). Local application of the olfactants 1,8-cineole and l-carvone to the VNO did not trigger autonomic responses or significant changes in the electroencephalographic pattern in male or in female subjects. Our studies indicate the adult human VNO is a functional chemosensory organ with a sexually dimorphic specificity and the ability to transduce signals which modulate certain autonomic parameters.

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药物

PH94B