行动的4-dihydropyridine导数,kw - 3049,在兔肠系膜动脉平滑肌膜。

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田农K,地震区K,冈K, Kitamura K,栗山H

行动的4-dihydropyridine导数,kw - 3049,在兔肠系膜动脉平滑肌膜。

Br J杂志。1987年11月,92(3):615 - 25所示。

PubMed ID

3427272 (在PubMed

]

文摘

1。的影响1、4-dihydro-2 6-dimethyl-4——(3-nitrophenyl) 3、5-pyridine-dicarboxylic酸甲基1 - (phenylmethyl) 3-piperidinyl酯盐酸盐(kw - 3049)在兔肠系膜动脉平滑肌膜研究使用微电极和单电极电压钳位的方法。2。在整个组织准备kw - 3049并没有改变静止膜电位的动脉,但抑制由去极化电流所引起的动作电位在10毫米四乙铵(茶)。3所示。使用电压钳技术,kw - 3049在内心的影响当前包含100毫米氯化钡诱发在溶液中被观察到。当膜举行-60 mV, kw - 3049抑制进口浓度的方式。的内向电流诱发更大的去极化脉冲抑制比这更大程度上诱发了较小的一个。4所示。膜举行-80 mV时,向内当前诱发电位测试的-10和0 mV被低浓度的增强kw - 3049(低于100海里)。 5. KW-3049 accelerated the rate of inactivation of the inward current and shifted the voltage-dependent inactivation curve to the left. 6. KW-3049 has a long-lasting inhibitory action on smooth muscle cells, since the inhibition of the inward current persisted for over 1 h after the removal of KW-3049. 7. Our results suggest that KW-3049 has a selective and long-lasting action on the Ca channels of the smooth muscle cell membrane of the rabbit mesenteric artery. This agent has both facilitatory and inhibitory actions on the Ca channel, depending on the values of the holding and command potentials.

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