雌激素的活性锌羟基吡啶硫酮:体内和体外研究。

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Yoon KS,只要N,顾H, Kwack SJ

雌激素的活性锌羟基吡啶硫酮:体内和体外研究。

环境卫生Toxicol。2017年2月9日,32:e2017004。doi: 10.5620 / eht.e2017004。eCollection 2017。

PubMed ID

28183164 (在PubMed

]

文摘

锌羟基吡啶硫酮(ZP)通常用于防止头皮屑和脂溢性皮炎。许多消费者每天接触高剂量的ZP,导致严重的对其毒性的关注。生殖和发育毒性以前发表在怀孕的老鼠。然而,ZP的雌激素活性不同程度的暴露已经很少了。因此,我们执行一个uterotrophic化验,E-screen分析,基因表达分析评估ZP的雌激素活性。uterotrophic化验,ZP(2 10或50毫克/公斤/天)每天切除卵巢的老鼠皮下注射了三天。子宫后提取24小时最后剂量。然后,湿和涂抹子宫重量测定。E-screen文章,MCF-7细胞(乳腺癌细胞株)暴露在10(9)到10(6)米ZP,然后测量细胞增殖。对基因表达分析、基因表达水平的变化在子宫样本uterotrophic试验进行了分析。 In the uterotrophic assay, the concentration of ZP had no significant effect on uterine weight. In the E-screen assay, ZP at any concentration showed no significant increase in MCF-7 cell proliferation, compared to the control group. However, 10(-6) M of ZP significantly reduced cell viability. The changes in gene expression slightly differed between the ZP and control groups. The in vivo and in vitro assays, together with gene expression analysis, demonstrated that ZP showed no significant estrogenic activity.

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药物

羟基吡啶硫酮