25 (OH) D2半衰期小于25 (OH) D3半衰期,受到菲律宾浓度和基因型的影响。
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琼斯KS,国年代,Harnpanich D,清汤R, Lambrechts D,普伦蒂斯,Schoenmakers我
25 (OH) D2半衰期小于25 (OH) D3半衰期,受到菲律宾浓度和基因型的影响。
中国性金属底座。2014年9月,99 (9):3373 - 81。doi: 10.1210 / jc.2014 - 1714。Epub 2014 6月2。
- PubMed ID
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24885631 (在PubMed]
- 文摘
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背景:有不确定性的等价维生素D2和D3维持等离子体浓度(25 (OH) D)。目的:这项研究的目的是比较25 (OH)的血浆半衰期D2和25 (OH) D3在两个不同的人群有不同的膳食钙摄入量和25 (OH) D的地位。参与者:健康男性(年龄在24岁和39 y),居民在冈比亚(n = 18)或英国(n = 18)参加了实验。干预措施:干预包括口服示踪剂deuterated-25 (OH) D2和deuterated-25 (OH) D3 (40 nmol)。收集血液样本在33天。主要结果测量:25 (OH) D2和25 (OH) D3血浆半衰期,25 (OH) D的浓度和维生素D结合蛋白(菲律宾)和菲律宾基因型测定。结果:25 (OH) D2半衰期(意思是(SD)] [13.9 (2.6) d]比25 (OH) D3的半衰期较短(15.1 d (3.1);P =措施]国家的总和,在冈比亚(12.8 vs 14.7 (3.5) (2.3) d d;P <措施),但不是在英国(15.1 vs 15.6 (2.5) (2.4) d d;P = 0。3)。 25(OH)D concentration was 69 (13) and 29 (11) nmol/L (P < .0001), and the DBP concentration was 259 (33) and 269 (23) mg/L (P = .4) in The Gambia and United Kingdom, respectively. Half-lives were positively associated with plasma DBP concentration for countries combined [25(OH)D2 half-life: regression coefficient (SE) 0.03 (0.01) d per 1 mg/L DBP, P = .03; 25(OH)D3 half-life: 0.04 (0.02) d, P = .02] and in Gambians [25(OH)D2 half-life: 0.04 (0.01) d; P = .02; 25(OH)D3 half-life: 0.06 (0.02) d, P = .01] but not in UK participants. The DBP concentration x country interactions were not significant. DBP Gc1f/1f homozygotes had shorter 25(OH)D2 half-lives compared with other combined genotypes (P = .007) after correction for country. CONCLUSIONS: 25(OH)D2 half-life was shorter than 25(OH)D3 half-life, and half-lives were affected by DBP concentration and genotype. The stable isotope 25(OH)D half-life measurements provide a novel tool to investigate vitamin D metabolism and vitamin D expenditure and aid in the assessment of vitamin D requirements.
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