Subchronic毒性的饮水和饲料中硫酸铜管理老鼠和老鼠。

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赫伯特CD,艾先生,Travlos GS,菲茨CJ,布赫JR

Subchronic毒性的饮水和饲料中硫酸铜管理老鼠和老鼠。

Fundam: Toxicol。1993年11月,21 (4):461 - 75。

PubMed ID

8253299 (在PubMed

]

文摘

急性中毒的影响由硫酸铜的物种是众所周知的;然而,慢性低级摄入硫酸铜的影响并没有得到很好的特点。人类因为接触可能发生硫酸铜通过饮用水、食物、土壤、或环境空气,subchronic毒性进行了研究在男性和女性F344 / N老鼠和B6C3F1小鼠的饮用水(两周接触),给饲料(2 -和13周曝光)路线。动物在那里进行评估,等待组织病理学、临床病理学、生殖毒性、和组织金属积累、靶器官检查通过多种特殊的着色剂和电子显微镜的观察病变。在饮用水、硫酸铜浓度300到100 ppm的没有产生不良影响,而3000到30000 ppm的浓度2周内致命的老鼠和老鼠。在饲料、硫酸铜浓度显著减少造成的4000到16000 ppm的身体体重2 - 13周研究的两个物种。增生、角化过度限制脊前胃在场的两个物种在2 - 13周的研究。老鼠服药饲料的研究中剂量增加肝脏的炎症和临床化学参数的变化表明肝细胞损伤和胆汁淤积。老鼠的肾脏组织学变化的剂量增加的数量和大小嗜酸性蛋白滴上皮细胞质和近曲小管腔。滴大,男性比女性多。 Urinalysis results were suggestive of renal tubular epithelial damage. Iron staining of spleens from treated animals indicated a marked depletion of iron stores in both male and female rats, but not in mice, while hematologic and clinical chemistry alterations in rats in the 13-week study, along with histologic changes in bone in the 2-week dosed feed study, were indicative of a microcytic anemia. Cupric sulfate produced no adverse effects on any of the reproductive parameters measured in rats or mice of either sex. These results indicate that cupric sulfate at high exposure levels is a hepatic and renal toxicant, as well as an inducer of anemia in rodents, with rats more sensitive than mice following subchronic exposure.

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药物

硫酸铜