药物动力学和带负电荷的果胶biodistribution纳米颗粒封装紫杉醇。

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时AK,库马尔

药物动力学和带负电荷的果胶biodistribution纳米颗粒封装紫杉醇。

癌症Nanotechnol。2013; 4 (4 - 5): 99 - 102。doi: 10.1007 / s12645 - 013 - 0041 - 8。Epub 2013年6月12日。

PubMed ID

26069505 (在PubMed

]

文摘

果胶、天然生物聚合物已经发现越来越多的应用在制药和生物技术行业。糖与三维结构对很多生物功能很重要。我们报告带负电荷的果胶的制备纳米颗粒封装紫杉醇,广谱抗癌药物可能的治疗应用。纳米颗粒的平均直径是300 - 350 nm ~ ~ 17%封装效率。TEM研究表明,粒子是球形的形状及其大小与DLS大小光谱一致。果胶聚合物的表面电荷是5 mV和纳米颗粒的~ -32 mV。增强的表面电荷显示更大的稳定性。电泳淌度高~ 3.5到1.5 mumcm / Vs证实的纳米粒子。我们比较紫杉醇的细胞毒性效应(罗马帝国)本身,果胶纳米颗粒(PPN)和果胶连锁店在消息灵通的G2,肝癌细胞系。存在剂量依赖的相关性观察细胞毒性,细胞毒性~ 21.7 + / - 3.2%被PPN观察,但罗马帝国本身显示~ 55.6 72 - h + / - 3.5%的细胞毒性试验。 The pharmacokinetics and biodistribution studies on Balb/c mice indicated that the nanoparticles had prolonged plasma retention of the drug with major accumulation in liver tissue after an i.v. tail vein injection of 20 mg/kg drug. The rank order of concentration are as follows, i.e., liver > kidney > lung > spleen for the PPN and spleen > liver > kidney >/= lung for Pax per se. The in vitro studies clearly indicated that the efficacy of the drug was not compromised by encapsulation, making it a good candidate to deliver biopharmaceuticals. Nanoparticles produced free radicals in the free cell system and this ability caused oxidative stress, which may give rise to inflammation, cell destruction, and genotoxicity. Thus, the results obtained in this study holds great promise for pectin nanoparticles to be exploited for passive delivery of paclitaxel to tumor tissues, in particular, liver cancers.

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药物

果胶