长期影响的维生素C和E,β-胡萝卜素,在年龄相关性黄斑变性和锌:火鸟报告没有。35。

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咀嚼,克莱蒙斯特,阿格龙E, Sperduto RD, Sangiovanni JP, Kurinij N,戴维斯博士

长期影响的维生素C和E,β-胡萝卜素,在年龄相关性黄斑变性和锌:火鸟报告没有。35。

眼科学。2013年8月,120 (8):1604 - 11. - e4。doi: 10.1016 / j.ophtha.2013.01.021。Epub 2013 4月10。

PubMed ID

23582353 (在PubMed

]

文摘

目的:描述长期影响(10年)的年龄相关性眼病研究(火鸟”)制定高剂量的抗氧化剂和锌补充剂年龄相关性黄斑变性(AMD)的进展。设计:多中心、随机、对照临床试验,紧随其后的是一个流行病学随访研究。参与者:我们招收了4757名参与者与AMD的不同程度的临床试验;3549年幸存的参与者同意后续研究。方法:实验的参与者被随机分配到抗氧化剂C, E和β-胡萝卜素和/或锌与安慰剂的临床试验。参与者的中级或高级AMD在1眼,火鸟配方延迟发展为先进的AMD。参与者参加后续研究。眼睛考试每年进行眼底照片和最佳矫正视力的评估。病史和死亡率均获得安全监测。重复测量在初选中使用逻辑回归分析。 MAIN OUTCOME MEASURES: Photographic assessment of progression to, or history of treatment for, advanced AMD (neovascular [NV] or central geographic atrophy [CGA]), and moderate visual acuity loss from baseline (>/=15 letters). RESULTS: Comparison of the participants originally assigned to placebo in AREDS categories 3 and 4 at baseline with those originally assigned to AREDS formulation at 10 years demonstrated a significant (P<0.001) odds reduction in the risk of developing advanced AMD or the development of NV AMD (odds ratio [OR], 0.66, 95% confidence interval [CI], 0.53-0.83 and OR, 0.60; 95% CI, 0.47-0. 78, respectively). No significant reduction (P = 0.93) was seen for the CGA (OR, 1.02; 95% CI, 0.71-1.45). A significant reduction (P = 0.002) for the development of moderate vision loss was seen (OR 0.71; 95% CI, 0.57-0.88). No adverse effects were associated with the AREDS formulation. Mortality was reduced in participants assigned to zinc, especially death from circulatory diseases. CONCLUSIONS: Five years after the clinical trial ended, the beneficial effects of the AREDS formulation persisted for development of NV AMD but not for CGA. These results are consistent with the original recommendations that persons with intermediate or advanced AMD in 1 eye should consider taking the AREDS formulation. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

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