黑升麻(Cimicifuga racemosa L.)治疗更年期早期症状的疗效:一项随机临床试验。
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穆罕默德-阿里扎德-查兰达比S，沙那兹M，纳海J，巴亚提帕扬S
黑升麻(Cimicifuga racemosa L.)治疗更年期早期症状的疗效:一项随机临床试验。
2013年11月1日;8(1):20。doi: 10.1186 / 1749-8546-8-20。
- PubMed ID
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24499633 (PubMed视图]
- 摘要
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背景:本研究旨在评价黑升麻(Cimicifuga racemosa L.)治疗早期绝经症状的疗效。方法:这项随机、双盲、安慰剂对照临床试验对84名格林更年期量表(GCS)评分为15至42的早期绝经后参与者进行，这些参与者于2011-2012年被转介到伊朗德黑兰的两个公共卫生保健中心。参与者被随机分配到治疗组(每天6.5毫克黑升麻干提取物)和对照组(安慰剂)，比例为1:1。参与者每天服用一片，持续8周。在治疗4周和8周后记录GCS评分。数据分析采用一般线性模型，采用SPSS软件进行重复测量。显著性水平设为P < 0.05。结果:8周治疗期间无随访损失。治疗组的GCS总评分(主要转归)在第4周[调整后平均差值:-7.8(95%可信区间:-11.1至-4.4)]和第8周[-12.9(-16.2至-9.3)]均显著低于对照组。治疗组在所有GCS亚量表评分(血管舒缩、精神、身体和性症状; secondary outcomes). The differences between the treatment and control groups at week 8 were significantly higher (P < 0.001) than those at week 4 in terms of the total scores and the vasomotor and psychiatric subscale scores. No side effects were reported. CONCLUSIONS: Black cohosh reduced the GCS total score and all GCS subscale scores (vasomotor, psychiatric, physical, and sexual symptoms) during 4 and 8 weeks of treatment. CLINICAL TRIAL REGISTRATION: This study was approved (Code 9061) by the Ethics Committee of Tabriz University of Medical Sciences and registered at the Iranian Registry of Clinical Trials with IRCT201107186709N4 on 15 January 2012.
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