肌醇:改善精子线粒体功能和精子运动性吗?

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Condorelli RA, La Vignera年代,Bellanca年代,Vicari E Calogero AE

肌醇:改善精子线粒体功能和精子运动性吗?

泌尿科,2012年6月,79 (6):1290 - 5。doi: 10.1016 / j.urology.2012.03.005。

PubMed ID

22656408 (在PubMed

]

文摘

目的:评估是否改善线粒体膜电位与精子的运动性有关改进和更大的精子复苏后游过过程。第二个目的是评估肌醇的影响(MYO)精子细胞凋亡,染色质压实质量,和DNA的完整性。方法:精子从20 normozoospermic男性和20 oligo-astheno-teratozoospermia患者体外孵化2毫克/毫升的MYO或磷酸盐作为控制2个小时。这个潜伏期后,精子的运动性评估。流式细胞仪是用于分析线粒体膜电位,磷脂酰丝氨酸外化,染色质密实度和DNA碎片。我们也评估精子的总数等恢复后游过孵化后MYO或磷酸盐。结果:肌显著增加精子的比例与进步的能动性normozoospermic男人和oligo-astheno-teratozoospermia患者。后者与能动性提高显著增加精子线粒体膜电位高的百分比。MYO没有对线粒体功能的影响从normozoospermic男性精子。精子磷脂酰丝氨酸外化、染色质密实度和DNA碎片被MYO两组不受影响。 After incubation with MYO, the total number of spermatozoa recovered after swim-up had improved significantly in both groups. CONCLUSION: These data show that MYO increases sperm motility and the number of spermatozoa retrieved after swim-up in both normozoospermic men and patients with abnormal sperm parameters. In patients with oligo-astheno-teratozoospermia, the improvement in these parameters was associated with improved sperm mitochondrial function. These findings support the use of MYO in both in vivo- and in vitro-assisted reproductive techniques.

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肌醇