评论文章:alginate-raft配方治疗胃灼热和胃酸倒流。
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曼德尔公斤,Daggy BP,布罗迪哒,雅各比你好
评论文章:alginate-raft配方治疗胃灼热和胃酸倒流。
滋养品杂志。2000年6月14日(6):669 - 90。
- PubMed ID
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10848650 (在PubMed]
- 文摘
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Alginate-based raft-forming配方一直是世界范围内进行销售30多年来在不同品牌,包括Gaviscon。他们是用于治疗胃灼热和食管炎,症状和出现的一个独特的机制与传统抗酸药不同。的胃酸,海藻酸盐沉淀,形成凝胶。Alginate-based raft-forming配方通常包含钠或碳酸氢钾;在胃酸的存在,碳酸氢转化为二氧化碳,就裹入内凝胶沉淀,将它转换成泡沫漂浮在胃内容物的表面,就像大量的水。在体外和体内研究表明alginate-based筏可以欺骗二氧化碳,以及抗酸剂组件中包含一些配方,从而提供一个相对pH-neutral障碍。几项研究已经证明,海藻酸筏可以优先进入食道,或未来,酸性胃内容物在集gastro-oesophageal回流;一些研究进一步表明,筏可以作为物理屏障来减少回流集。尽管一些alginate-based配方也含有抗酸剂组件可以提供重要的酸中和能力,这些配方以减少烧心症状的功效似乎并不完全依赖于大量胃内容物的中和。海藻酸筏的强度取决于几个因素,包括生成的二氧化碳量和禁锢在筏子,海藻酸的分子特性,存在铝或钙的抗酸剂成分配方。 Raft formation occurs rapidly, often within a few seconds of dosing; hence alginate-containing antacids are comparable to traditional antacids for speed of onset of relief. Since the raft can be retained in the stomach for several hours, alginate-based raft-forming formulations can additionally provide longer-lasting relief than that of traditional antacids. Indeed, clinical studies have shown Gaviscon is superior to placebo, and equal to or significantly better than traditional antacids for relieving heartburn symptoms. Alginate-based, raft-forming formulations have been used to treat reflux symptoms in infants and children, and in the management of heartburn and reflux during pregnancy. While Gaviscon is effective when used alone, it is compatible with, and does not interfere with the activity of antisecretory agents such as cimetidine. Even with the introduction of new antisecretory and promotility agents, alginate-rafting formulations will continue to have a role in the treatment of heartburn and reflux symptoms. Their unique non-systemic mechanism of action provides rapid and long-duration relief of heartburn and acid reflux symptoms.