Triketocholanoic (dehydrocholic)酸。肝代谢和影响胆汁流和胆汁脂质分泌的男人。
文章的细节
-
引用
复制到剪贴板 -
Soloway RD,霍夫曼AF,托马斯•PJ Schoenfield LJ,克莱因PD
Triketocholanoic (dehydrocholic)酸。肝代谢和影响胆汁流和胆汁脂质分泌的男人。
中国投资。1973年3月,52 (3):715 - 24。doi: 10.1172 / JCI107233。
- PubMed ID
-
4685091 (在PubMed]
- 文摘
-
[24 - (14)C] Dehydrocholic酸(triketo-5-beta-cholanoic酸)是合成胆酸(24 ~ (14)C),和200毫克的载体混合,进行静脉注射两留置T管设计,允许患者胆汁不中断抽样的肝肠循环。超过80%的注入放射性迅速分泌胆汁,甘氨酸,taurine-conjugated胆汁酸。放射性产品识别,早期解离后,部分或完全dehydrocholic酸的衍生品。通过质谱分析,以及色谱的主要代谢物(大约70%)是二羟基monoketo胆汁酸(3α7 alpha-dihydroxy-12-keto-5beta-cholanoic酸);第二个代谢物(大约20%)是一羟基的diketo酸(3 alpha-hydroxy-7 12-di-keto-5beta-cholanoic酸);和大约10%的放射性出现胆酸。减少似乎是顺序(3位置,然后7的位置,然后12位置)和立体定向(只有α异构体被恢复)。胆汁流,表示为胆汁酸排泄胆汁流量的比率,增加dehydrocholic酸后管理。这是推测hydrocholeretics羟基酮代谢物。胆固醇、卵磷脂和胆酸的比例没有显著改变dehydrocholic酸后管理。 In vitro studies showed that the hydroxy keto metabolites dispersed lecithin poorly compared to cholate; however, mixtures of cholate and either metabolite had dispersant properties similar to those of cholate alone, provided the ratio of metabolite to cholate remained below a value characteristic for each metabolite. These experiments disclose a new metabolic pathway in man, provide further insight into the hydrocholeresis induced by keto bile acids, and indicate the striking change in pharmacologic and physical properties caused by replacement of hydroxyl by a keto substituent in the bile acid molecule.
DrugBank数据引用了这篇文章
- 药物