阻塞CGRP怎样在偏头痛患者的利弊。
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迪恩M, Correnti E,卡姆K, Kelderman T, Papetti L, Rubio-Beltran E, Vigneri年代,Edvinsson L, Maassen Van Den边缘
阻塞CGRP怎样在偏头痛患者的利弊。
J头痛。2017年9月25日,18 (1):96。doi: 10.1186 / s10194 - 017 - 0807 - 1。
- PubMed ID
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28948500 (在PubMed]
- 文摘
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偏头痛是全世界最普遍的神经紊乱和巨大的社会经济影响。目前,对偏头痛的预防治疗方案包括药物开发用于偏头痛以外的疾病,如高血压、抑郁症和癫痫。在过去的十年中,然而,阻塞降钙素相关基因肽(CGRP怎样)已成为预防偏头痛发作的可能机制。CGRP怎样已被证明是在偏头痛发作时释放可能发挥决定性作用感应偏头痛的原因。在这里,我们审查的利弊阻塞CGRP怎样在偏头痛患者。到目前为止,两种不同类型的药物阻断CGRP怎样开发:小分子CGRP怎样受体拮抗剂(有)单克隆抗体,针对CGRP怎样或CGRP怎样受体。进行了试验测试这些药物的疗效和安全性。一般来说,疗效优于安慰剂已经证明,特别是关于抗体。此外,目前使用的功效符合其他预防性治疗。药物也被容忍,除了一些有诱导转氨酶短暂的增加。 Thus, blocking CGRP in migraine patients is seemingly both efficient and well tolerated. However, CGRP and its receptor are abundantly present in both the vasculature, and in the peripheral and central nervous system, and are involved in several physiological processes. Therefore, blocking CGRP may pose a risk in subjects with comorbidities such as cardiovascular diseases. In addition, long-term effects are still unknown. Evidence from animal studies suggests that blocking CGRP may induce constipation, affect the homeostatic functions of the pituitary hormones or attenuate wound healing. However, these effects have so far not been reported in human studies. In conclusion, this review suggests that, based on current knowledge, the pros of blocking CGRP in migraine patients exceeds the cons.
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- 药物