丁香酚的代谢。

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通用电气,费舍尔IU,冯安鲁Dengler HJ

丁香酚的代谢。

Xenobiotica。1990年2月,20(2):209 - 22所示。

PubMed ID

2333717 (在PubMed

]

文摘

1。丁香酚的代谢(4-hydroxy-3-methoxy-allylbenzene)考察了男性和女性的健康志愿者。口服后迅速吸收和代谢,几乎完全在尿液中排出在24 h。菊尿液中丁香酚达不到0.1%的剂量。2。尿液含有配合丁香酚和九个代谢物。这些代谢物的结构,使用g.l.c阐明。质谱,通过比较合成参考化合物,被确定为:丁香酚,4-hydroxy-3-methoxyphenyl-propane,独联体,trans-isoeugenol 3 - (4-hydroxy-3-methoxyphenyl) -propylene-1 2-oxide, 3 - (4-hydroxy-3-methoxyphenyl) -propane-1,可,3 - (4-hydroxy-3-methoxyphenyl)丙酸。3所示。下面的代谢物的结构从质谱初步推断,参考化合物并不可用:3-hydroxy-3——(4-hydroxy-3-methoxyphenyl) -allylbenzene 3 - (6 ? -mercapto-4-hydroxy-3-methoxyphenyl)丙烷和2-hydroxy-3——(4-hydroxy-3-methoxyphenyl)丙酸。4所示。 The amounts of the individual metabolites excreted were determined by g.l.c. Some 95% of the dose was recovered in the urine, most of which (greater than 99%) consisted of phenolic conjugates; 50% of the conjugated metabolites were eugenol-glucuronide and sulphate. Other metabolic routes observed were the epoxide-diol pathway, synthesis of a thiophenol and of a substituted propionic acid, allylic oxidation, and migration of the double bond.

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药物

丁香油