苯妥英和氟尿嘧啶相互作用
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Gilbar PJ, Brodribb TR
苯妥英和氟尿嘧啶相互作用
Ann Pharmacother. 2001 11月35(11):1367-70。doi: 10.1345 / aph.1A051。
- PubMed ID
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11724084 (PubMed视图］
- 摘要
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目的:报道苯妥英与氟尿嘧啶之间可能的药物相互作用。病例报告:一名66岁的白人男子开始辅助化疗结肠癌与每周丸注射氟尿嘧啶和亚叶酸钙。他服用苯妥英300mg /d治疗癫痫已超过4年。11周后，据报道，患者脚步不稳，并摔倒了几次。当时血清苯妥英浓度为36 μ g/mL。苯妥英剂量减少，症状缓解。在剩余的15周氟尿嘧啶治疗期间，监测苯妥英浓度并相应地调整剂量。化疗结束后，苯妥英剂量逐渐增加到原剂量，无毒性迹象。讨论:苯妥英主要由CYP2C9代谢。氟尿嘧啶对同工酶的抑制，以及对其合成的干扰，似乎是这种相互作用最有可能的原因。 The reduction in saturating substrate concentration of phenytoin was reduced as a result of this interaction, thus causing decreased clearance and increased serum concentrations. No previous interaction between phenytoin and fluorouracil has been reported. Both phenytoin and warfarin are metabolized by CYP269 and therefore exhibit the same spectrum of interactions when that isoenzyme is inhibited. Interactions have been reported with concurrent administration of warfarin and fluorouracil. CONCLUSIONS: The nature and extent of this phenytoin-fluorouracil interaction should be elucidated by in vitro investigations and a prospective study. Until then, clinicians should be aware of this potentially serious drug interaction and monitor patients closely for phenytoin toxicity.
引用本文的药物库数据
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药物 酶 种类 生物 药理作用 行动 氟尿苷 细胞色素P450 2C9 蛋白质 人类 未知的抑制剂细节 氟尿嘧啶 细胞色素P450 2C9 蛋白质 人类 未知的抑制剂细节 - 药物的相互作用Learn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
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药物 交互 整合药物之间
软件中的交互
