插件可以影响- 00023,一本小说,1选择性5 -羟色胺受体激动剂的措施在广泛性焦虑:焦虑和抑郁的结果双盲,安慰剂对照试验。
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Rickels K,马修,Banov医学博士Zimbroff DL, Oshana年代,帕森斯EC Jr, Donahue SR,考夫曼M,艾耶GR,莱因哈德摩根富林明Jr
插件可以影响- 00023,一本小说,1选择性5 -羟色胺受体激动剂的措施在广泛性焦虑:焦虑和抑郁的结果双盲,安慰剂对照试验。
中国Psychopharmacol。2008年4月28日(2):235 - 9。doi: 10.1097 / JCP.0b013e31816774de。
- PubMed ID
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18344738 (在PubMed]
- 文摘
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插件可以- 00023 1 5 -羟色胺受体激动剂,旨在提供高强度和选择性的目标。评估可能的治疗效用焦虑,一项随机、双盲、安慰剂对照试验在311年进行了受试者符合标准的精神障碍的诊断与统计手册第四版,广泛性焦虑障碍。所有的受试者都接受1周安慰剂争执,被随机分配接受每天换一次胶囊包含插件可以- 00023 (80 mg / d)为一个额外的8周或安慰剂。主要结果测量指标是汉密尔顿焦虑量表(HAM-A)。内在蒙哥马利抑郁量表被用作二次端点测量抑郁症状。统计测试进行协方差分析,在基线和第八周之间,与基线值作为协变量。- 00023的抗焦虑效果插件可以与安慰剂相比,显示趋势在所有抗焦虑的措施,但未能达到意义的主要终点(HAM-A总分)。在HAM-A总分的组件中,焦虑情绪项目明显不同于安慰剂- 00023的插件可以治疗组(-1.015 vs -0.748;P = 0.02)。内在蒙哥马利抑郁量表的得分显著提高与安慰剂相比在第八周(-4.5 vs -1.6; P = 0.0094 in the last observation carried forward analysis). PRX-00023 was well tolerated; of note, there were no drug-related serious adverse events, and more patients discontinued due to adverse events in the placebo group (2.9%) than in the PRX-00023 group (1.4%). The most common adverse event was headache, observed in 15.7% and 10.9% of PRX-00023- and placebo-treated patients, respectively. Furthermore, there was no evidence of impaired sexual function, as measured by the Massachusetts General Hospital Sexual Function Scale. Collectively, these results support further clinical investigation of higher doses of PRX-00023 in anxiety and depression.