GLP-1减少肠淋巴流量、甘油三酸酯的吸收和载脂蛋白生产的老鼠。

文章的细节

引用

复制到剪贴板

秦X,沈H,刘M,杨问,郑年代,Sabo M, D 'Alessio哒,Tso P

GLP-1减少肠淋巴流量、甘油三酸酯的吸收和载脂蛋白生产的老鼠。

是杂志Gastrointest肝脏杂志。2005年5月,288 (5):G943-9。Epub 2005年1月27日。

PubMed ID

15677555 (在PubMed

]

文摘

Glucagon-like肽1 (GLP-1)是一种胃肠激素分泌针对膳食摄入enteroendocrine L细胞主要位于降低小肠和大肠。GLP-1抑制分泌和能动性的肠道和一直在建议中发挥作用的“回肠制动”。In this study, we investigated the effect of recombinant GLP-1-(7-36) amide (rGLP-1) on lipid absorption in the small intestine in intestinal lymph duct-cannulated rats. In addition, the effects of rGLP-1 on intestinal production of apolipoprotein (apo) B and apo A-IV, two apolipoproteins closely related to lipid absorption, were evaluated. rGLP-1 was infused through the jugular vein, and lipids were infused simultaneously through a duodenal cannula. Our results showed that infusion of rGLP-1 at 20 pmol.kg(-1).min(-1) caused a dramatic and prompt decrease in lymph flow from 2.22 +/- 0.15 (SE) ml/h at baseline (n = 6) to 1.24 +/- 0.06 ml/h at 2 h (P < 0.001). In contrast, a significant increase in lymph flow was observed in the saline (control) group: 2.19 +/- 0.20 and 3.48 +/- 0.09 ml/h at baseline and at 6 h of lipid infusion, respectively (P < 0.001). rGLP-1 also inhibited intestinal triolein absorption (P < 0.05) and lymphatic apo B and apo A-IV output (P < 0.05) but did not affect cholesterol absorption. In conclusion, rGLP-1 dramatically decreases intestinal lymph flow and reduces triglyceride absorption and apo B and apo A-IV production. These findings suggest a novel role for GLP-1 in lipid absorption.

DrugBank数据引用了这篇文章

药物

rGLP-1