术中检测结直肠癌radioimmunoguided手术和CC49,第二代单克隆抗体。
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阿诺兆瓦,Schneebaum年代,焦点,小L, Mojzisik C,亨克尔克,马丁电子战Jr
术中检测结直肠癌radioimmunoguided手术和CC49,第二代单克隆抗体。
安Surg. 1992年12月,216 (6):627 - 32。
- PubMed ID
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1466615 (在PubMed]
- 文摘
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Radioimmunoguided手术(平台)一直在使用参考例结直肠癌评估局部肿瘤的扩散和转移性疾病的严重程度。这种技术使用放射性标记的单克隆抗体(mab)针对肿瘤相关抗原和手持gamma-detection探针检测肿瘤组织的radiolabel固定。最近推出了一个马伯针对肿瘤相关糖蛋白(anti-TAG) CC49。60例进入初步研究。十八21(86%)的主要肿瘤局部CC49马伯和gamma-detecting调查。29 30(97%)复发肿瘤局部。抗体剂量并不影响本地化。标本分为组织类型我通过第四,基于抗体本地化和苏木精和伊红染色()):I型,钻井平台(-)及基质(-);II型,钻井平台(-)及基质(+);类型III,钻井平台(+)及基质(-); type IV, RIGS (+) and histologically (+). Type IV tissue were further classified by whether they were grossly apparent, IVa, or grossly inapparent, IVb (occult). Occult tumor found by RIGS and confirmed by H&E staining (type IV) had localization ratios similar to RIGS-positive, histology-negative tissue (type III). Traditionally found cancer (type IV) had significantly higher ratios. In 12 of 24 patients (50%) with primary tumors and 14 of 30 patients (47%) with recurrent tumors, RIGS with CC49 altered the planned operative procedure. Radioimmunoguided surgery with CC49 provides useful, immediate intraoperative information not available by other techniques.
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