环丙沙星在健康受试者的茶碱药物动力学的影响。

文章的细节

引用

古怪的KT,戴维斯TM, Ilett KF, Dusci LJ,老兰顿

环丙沙星在健康受试者的茶碱药物动力学的影响。

Br中国新药杂志。1995年3月,39(3):305 - 11所示。

PubMed ID
7619673 (在PubMed
]
文摘

1。环丙沙星、茶碱之间的交互机制研究在9个健康受试者。2。对象都被赋予了一项单一的口服剂量的茶碱(3.4毫克公斤),之前和之后的60 h(环丙沙星治疗的剂量500毫克每日两次。3所示。环丙沙星口服茶碱的间隙减少了19%(-7.73 + / - 6.42毫升的h -公斤(95%可信限-12.66,-2.79)。一些科目(A组,n = 4)显示小间隙减少(意思是4.4%;-1.6 + / - 0.7毫升的h -公斤(-2.6,0.5)),而其他人(B组,n = 5)显示明显减少(意思是30%;-12.7 + / - 3.7毫升的h -公斤(-17.2,-8.1))。4所示。 Comparing groups A and B, the decrease in oral clearance of theophylline in group B could not be ascribed to differences in the AUC of ciprofloxacin. Group A subjects showed only slight inhibition of 1-demethylation (-12.8 +/- 5.5% (-21.5, -4.0)), while group B subjects showed a significantly greater inhibition of 1-demethylation (-49.9 +/- 9.8% (-62.1, -37.7)), 3-demethylation (-44.8 +/- 8.6% (-55.4, -34.1)) and 8-hydroxylation (-27.0 +/- 3.7% (-31.6, -22.4)). 5. The results suggest that inter-individual variability in the inhibition of theophylline metabolism by ciprofloxacin can be attributed to inter-individual differences in the level of CYP1A2 expression and/or in the degree of inhibition of hepatic CYP1A2 and CYP3A4. 6. The interaction between ciprofloxacin and theophylline can be clinically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

DrugBank数据引用了这篇文章

药物酶
药物 生物 药理作用 行动
环丙沙星 细胞色素P450 1 a2 蛋白质 人类
未知的
抑制剂
细节
锝tc - 99 m环丙沙星 细胞色素P450 1 a2 蛋白质 人类
没有
抑制剂
细节