环丙沙星在健康受试者的茶碱药物动力学的影响。
文章的细节
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引用
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古怪的KT,戴维斯TM, Ilett KF, Dusci LJ,老兰顿
环丙沙星在健康受试者的茶碱药物动力学的影响。
Br中国新药杂志。1995年3月,39(3):305 - 11所示。
- PubMed ID
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7619673 (在PubMed]
- 文摘
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1。环丙沙星、茶碱之间的交互机制研究在9个健康受试者。2。对象都被赋予了一项单一的口服剂量的茶碱(3.4毫克公斤),之前和之后的60 h(环丙沙星治疗的剂量500毫克每日两次。3所示。环丙沙星口服茶碱的间隙减少了19%(-7.73 + / - 6.42毫升的h -公斤(95%可信限-12.66,-2.79)。一些科目(A组,n = 4)显示小间隙减少(意思是4.4%;-1.6 + / - 0.7毫升的h -公斤(-2.6,0.5)),而其他人(B组,n = 5)显示明显减少(意思是30%;-12.7 + / - 3.7毫升的h -公斤(-17.2,-8.1))。4所示。 Comparing groups A and B, the decrease in oral clearance of theophylline in group B could not be ascribed to differences in the AUC of ciprofloxacin. Group A subjects showed only slight inhibition of 1-demethylation (-12.8 +/- 5.5% (-21.5, -4.0)), while group B subjects showed a significantly greater inhibition of 1-demethylation (-49.9 +/- 9.8% (-62.1, -37.7)), 3-demethylation (-44.8 +/- 8.6% (-55.4, -34.1)) and 8-hydroxylation (-27.0 +/- 3.7% (-31.6, -22.4)). 5. The results suggest that inter-individual variability in the inhibition of theophylline metabolism by ciprofloxacin can be attributed to inter-individual differences in the level of CYP1A2 expression and/or in the degree of inhibition of hepatic CYP1A2 and CYP3A4. 6. The interaction between ciprofloxacin and theophylline can be clinically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
DrugBank数据引用了这篇文章
- 药物酶
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药物 酶 类 生物 药理作用 行动 环丙沙星 细胞色素P450 1 a2 蛋白质 人类 未知的抑制剂细节 锝tc - 99 m环丙沙星 细胞色素P450 1 a2 蛋白质 人类 没有抑制剂细节