(雄激素(睾酮和脱氢表雄酮硫酸盐)浓度之间的关系,在非肥胖老年人代谢综合征)。

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Rabijewski M, Papierska L, Kozakowski J, Zgliczynski W

(雄激素(睾酮和脱氢表雄酮硫酸盐)浓度之间的关系,在非肥胖老年人代谢综合征)。

Endokrynol波尔。2007年11 - 12月,58 (6):496 - 504。

PubMed ID
18205106 (在PubMed
]
文摘

简介:代谢综合征的特点是中央肥胖、胰岛素和血脂失调,与高血压、动脉粥样硬化过程是一个前兆的状态,结果是,心血管疾病。下降睾丸和肾上腺功能老化导致男性雄激素浓度降低。假设,低水平的总睾酮和脱氢表雄酮硫酸盐(硫酸脱氢表雄酮(dhea - s)与不利的水平相关联的几个强大的心血管疾病危险因素,如脂质和血液快乐,是代谢综合征的组件,和胰岛素水平。睾酮与硫酸脱氢表雄酮(dhea - s不足是肥胖和胰岛素抵抗的危险因素,但目前尚不清楚这是否可能的影响是独立的。本研究的目的是确定是否降低雄激素(睾酮、硫酸脱氢表雄酮(dhea - s)水平与代谢综合征的发展非肥胖老年人以及分析,是否这些性激素影响分别测量参数。材料和方法:85人年龄从60到70岁(平均66.3 + / - 1.5年;意思是+ / - SEM)进行了分析。睾酮水平< 4 ng / ml或脱氢表雄酮水平< 2000 ng / ml和BMI < 30公斤/米(2)包括标准。患者分为三组:52,睾丸素不足(L-T), 32和脱氢表雄酮缺乏症(L-DHEA-S)和67缺乏性激素(L-T /硫酸脱氢表雄酮(DHEA - s)。性激素的影响缺乏这些组在血压、脂肪、内脏肥胖和空腹血糖测定(根据代谢综合征定义第三NCEP / IDF)。 RESULTS: Testosterone levels in L-T, L-DHEA and L-T/DHEA-S groups were respectively 3.19 +/- 0.23 ng/ml, 4.89 +/- 0.45 ng/ml and 3.25 +/- 0.34 g/ml (p < 0.002). While DHEA-S levels were respectively 2498 +/- 98 ng/ml, 1435 +/- 1010 ng/ml and 1501 +/- +/- 89 ng/ml). BMI values do not differ between groups. Waist circumference was significantly higher in L-T/DHEA-S group than in L-T i L-DHEA-S groups (respectively: 99.9 +/- 6,1 cm, 97.1 +/- 7.1 cm i 96.2 +/- 6.4 cm; mean +/- SD, p < 0.05 vs. L-T and L-DHEA-S groups). Mean triglycerides concentration in L-T/DHEA-S group was significantly higher than in L-T and L-DHEA-S groups (respectively: 188.2 +/- 13.3 mg/dl, 161.7 +/- 14.7 mg/dl and 152.2 +/- 12.8 mg/dl (mean +/- SD; p < 0.02 vs. L-T and L-DHEA-S groups). Analysis of prevalence of risk factors showed, that in L-T/DHEA-S group they were more frequent than in other groups. The most significant percentage difference was observed for triglycerides: concentration > or = 150 mg/dl was measured in 31% men in L-T group, 28% men in L-DHEA-S group and 42% men in L-T/DHEA-S group. According metabolic syndrome definition NCEP III/IDF prevalence of this syndrome was: 71% patients in L-T/DHEA-S group, 67% patients in L-T group and 64% patients in L-DHEA-S group. CONCLUSIONS: The DHEA-S and testosterone deficiency was a significant and independent risk factor of the metabolic syndrome in non-obese elderly men. It seems, that triglycerides concentration and waist circumference are more sensitive then others parameters to reflect the influence of sex hormones deficiency on risk of the metabolic syndrome in elderly men.

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