反式钠为出血性休克crocetinate:延时初始治疗的效果。
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波因特AK Giassi LJ,获得者杰
反式钠为出血性休克crocetinate:延时初始治疗的效果。
冲击。2002年12月,18 (6):585 - 8。
- PubMed ID
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12462570 (在PubMed]
- 文摘
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一种新药,反式钠crocetinate (TSC),被建议用于创伤后复苏。TSC被证明能增加生存在出血性休克大鼠模型。这也导致增加血压和降低血浆乳酸水平时后出血。TSC全身耗氧量增加利率,它认为它的生理作用是由于增加氧的可用性。事实上,TSC疗法和100%氧气疗法使用时显示类似的结果在同一大鼠出血模型。然而,有人建议,100%的氧气疗法是有效的只有开始后出血。这样的一个机会之窗已经说存在其他复苏方法;因此,当前的研究是为TSC确定这是真的。一系列的实验,老鼠流血60%的血液量和注射的TSC(或盐水)出血后20分钟结束。注射然后重复四次,间距为10分钟。 Thirty minutes after the final injection, the animals were infused with normal saline. TSC again restored blood pressure and other parameters, but repeated dosing was necessary. In addition, this therapy prevented an increase in liver enzymes (transaminases) as measured 24 h after hemorrhage. In a second study, rats were bled 60% of their blood volumes, followed by a second bleeding (an additional 10%) done 10 min later. No subsequent fluid was infused in this group. The majority of the animals treated with TSC after the second hemorrhage survived, whereas the controls did not. These data suggest that TSC is effective when given after a delay. The dosing regimen must be different, however, presumably because of the blood acidosis that develops after hemorrhage. The results also suggest that TSC may be protective against secondary liver damage resulting from trauma.
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