latanoprost bimatoprost的作用机制,在健康受试者travoprost。一个交叉研究。

文章的细节

引用
复制到剪贴板

Lim KS、nautica CB奥MM,霍奇,环面CB,迈凯轮JW,约翰逊DH

latanoprost bimatoprost的作用机制,在健康受试者travoprost。一个交叉研究。

眼科学。2008年5月,115 (5):790 - 795. - e4。doi: 10.1016 / j.ophtha.2007.07.002。

PubMed ID
18452763 (在PubMed
]
文摘

目的:研究3前列腺素类似物的影响,bimatoprost, latanoprost,和travoprost水动力学在同一主题和流出的评估比较技术设施。设计:实验研究(双盲、安慰剂对照、随机成对比较,4-period交叉)。参与者:三十健康成年受试者。方法:Bimatoprost, latanoprost、travoprost或安慰剂注射到左眼每天晚上7天,之后至少四周每个会话之间的洗脱期。Tonographic房水流畅系数是衡量Schiotz眼压描记和pneumatonography 7天。8天,房水流量和fluorophotometric房水荧光光度测定法测定。Uveoscleral流出计算房水流量和房水流畅使用Goldmann方程。主要结果测量:设施流出,房水流量、眼内压(IOP),计算uveoscleral流出。结果:所有药物降低眼压相对于安慰剂。没有药物影响房水生产。 All medications increased outflow facility compared with placebo when measured by Schiotz and 2-minute pneumatonography (P< or =0.02); the apparent increase of outflow facility measured with fluorophotometry and 4-minute pneumatonography did not reach statistical significance. In contrast, uveoscleral outflow was significantly increased by all medications when calculated from 4-minute pneumatonography data, and fluorophotometry and Schiotz data at higher episcleral venous pressures. The apparent increase found with 2-minute pneumatonography did not reach statistical significance. These differing results in the same patients indicate that differences in measurement techniques, and not differences in mechanism of action, explain previous conflicting published reports on the mechanism of action of the prostaglandins. CONCLUSIONS: Bimatoprost, latanoprost, and travoprost have similar mechanisms of action. All 3 drugs reduce IOP without significantly affecting the aqueous production rate. All drugs increase aqueous humor outflow, either by enhancing the pressure-sensitive (presumed trabecular) outflow pathway or by increasing the pressure-insensitive (uveoscleral) outflow, but the assessment of the amount of flow through each pathway depends upon the measurement technique.

DrugBank数据引用了这篇文章

药物
药物靶点
药物 目标 类 生物 药理作用 行动
Bimatoprost 前列腺素F2-alpha受体 蛋白质 人类
是的
受体激动剂
 细节
Travoprost 前列腺素F2-alpha受体 蛋白质 人类
是的
受体激动剂
 细节