缺血性中风基因研究的荟萃分析:32个基因，涉及约18,000例病例和58,000个对照组。
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Casas JP, Hingorani AD, Bautista LE, Sharma P
缺血性中风基因研究的荟萃分析:32个基因，涉及约18,000例病例和58,000个对照组。
神经弓杂志2004年11月61(11):1652-61。
- PubMed ID
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15534175 (PubMed视图］
- 摘要
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缺血性中风被认为具有多基因基础，但中风易感基因的鉴定和相关风险的量化一直受到来自不足的病例对照研究的相互矛盾的结果的阻碍。我们对缺血性中风的所有候选基因关联研究进行了荟萃分析。电子数据库在2003年1月之前检索了英语期刊上所有与必威国际app人类缺血性中风任何候选基因调查相关的病例对照和嵌套病例对照研究。病例需要有诊断的神经影像学证据。为了保持遗传同质性，只纳入了成年白人的研究。评估数量性状或中间表型的研究被排除在外。纳入了120项病例对照研究的数据。计算随机效应和固定效应模型95%置信区间的合并优势比(ORs)。在研究的32个基因中，确定了15个多态性，至少进行了3项研究。因子V Leiden Arg506Gln与缺血性卒中的相关性具有统计学意义(OR, 1.33; 95% CI, 1.12-1.58), methylenetetrahydrofolate reductase C677T (OR, 1.24; 95% CI, 1.08-1.42), prothrombin G20210A (OR, 1.44; 95% CI, 1.11-1.86), and angiotensin-converting enzyme insertion/deletion (OR, 1.21; 95% CI, 1.08-1.35). These were also the most investigated candidate genes, including 4588, 3387, 3028, and 2990 cases, respectively. No statistically significant association with ischemic stroke was detected for the 3 next most investigated genes (factor XIII, apolipoprotein E, and human platelet antigen type 1). There is a genetic component to common stroke. No single gene with major effect was identified; rather, common variants in several genes, each exerting a modest effect, contribute to the risk of stroke. These findings have important implications for the design of future genetic studies and for predictive genetic testing for stroke and other multifactorial diseases.