雄激素受体基因中的CAG重复及其与前列腺癌的关系。
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乔凡努奇E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH, Kantoff PW
雄激素受体基因中的CAG重复及其与前列腺癌的关系。
1997年4月1日;94(7):3320-3。
- PubMed ID
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9096391 (在PubMed］
- 摘要
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雄激素受体基因中出现的多态CAG重复序列的长度与雄激素受体的转录活性呈负相关。由于增强的雄激素刺激可能增加前列腺癌发生和进展的风险，我们研究了雄激素受体基因中较短的CAG重复序列是否与前列腺癌的更高风险相关。我们在《医师健康研究》中对1982年至1995年间确诊的587例前列腺癌新诊断病例和588例未患前列腺癌的对照组进行了嵌套病例对照研究。雄激素受体基因CAG重复次数越少，总前列腺癌风险越高[相对风险(RR) = 1.52;95%置信区间(CI) = 0.92-2.49;P趋势= 0.04;对于CAG重复长度<或= 18相对于>或= 26重复的男性]。特别是，较短的CAG重复序列与以前列腺外延伸或远处转移(C期或D期)或高组织学分级为特征的癌症相关(RR = 2.14;CI = 1.14 - -4.01;P趋势= 0.001)。 This association was observed individually both for high stage (RR = 2.23) and high grade prostate cancer (RR = 1.89). Men with shorter repeats were at particularly high risk for distant metastatic and fatal prostate cancer. Variability in the CAG repeat length was not associated with low grade or low stage disease. These results demonstrate that a shorter CAG repeat sequence in the androgen receptor gene predicts higher grade and advanced stage of prostate cancer at diagnosis, and metastasis and mortality from the disease. The clinical implications of these results should be evaluated further.