Hydromorphone急性和慢性疼痛。

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奎格利C

Hydromorphone急性和慢性疼痛。

科克伦数据库系统启2002;(1):CD003447。

PubMed ID

11869661 (在PubMed

]

文摘

背景:虽然吗啡的黄金标准的管理严重的癌症疼痛,有些病人不能达到充分镇痛,或遭受难以忍受的morphine-related毒性。对于这些患者选择hydromorphone等建议。然而,似乎差距对我们理解hydromorphone的有效性和效力。目的:本文探讨和评估的有效性的证据hydromorphone管理疼痛。必威国际app搜索策略:随机试验包括hydromorphone被handsearching寻求使用电子数据库和相关期刊。最近搜索日期:2000年2月。必威国际app选择标准:相关的涉及hydromorphone管理,对急性和慢性疼痛,在成人和儿童,包括在内。数据收集和分析:一种数据提取的目的是为审查。每个试验包含的有效性评估使用Cochrane手册中描述的标准。是分配给每个年级的研究的基础上分配隐藏。 A checklist was used to assess blinding. MAIN RESULTS: Forty three studies (2725 subjects) were included in the review. Approximately half of these studies received a low quality score. In addition, the heterogeneity of the studies precluded combination of data and results. A meta-analysis was therefore not possible. Of the 43 included studies, 11 (645 subjects) involved chronic pain conditions (all cancer) and 32 (2080 subjects) acute pain. Three studies were placebo-controlled. Of the remainder, hydromorphone was compared with other opioids (morphine, fentanyl, sufentanyl, meperidine, oxycodone, diamorphine), bupivicaine and with itself, using different formulations. The routes of administration included intravenous, oral, spinal, intramuscular and subcutaneous. Overall, hydromorphone appears to be a potent analgesic. The limited number of studies available suggest that there is little difference between morphine and hydromorphone in terms of analgesic efficacy, adverse effect profile and patient preference. However, as most studies involved small numbers of patients, it is difficult to determine real differences between both drugs. In the context of both acute and chronic pain, the issue of equi-analgesic ratios between morphine and hydromorphone was not resolved. REVIEWER'S CONCLUSIONS: The studies included in this review were varied in terms of quality and methodology. However, the majority demonstrated that hydromorphone is a potent analgesic, that the clinical effects of hydromorphone appear to be dose-related, and that the adverse effect profile of hydromorphone is similar to that of other mu opioid receptor agonists.

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药物靶点

药物	目标	类	生物	药理作用	行动
Hydromorphone	Mu-type阿片受体	蛋白质	人类	是的	受体激动剂	细节