怀孕对一氧化氮和前列腺素的角色5-hydroxytryptamine-induced收缩在老鼠孤立的胸和腹主动脉。

文章的细节

引用

复制到剪贴板

Bobadilla L RA, Perez-Alvarez V, Bracho巴尔德斯,Lopez-Sanchez P

怀孕对一氧化氮和前列腺素的角色5-hydroxytryptamine-induced收缩在老鼠孤立的胸和腹主动脉。

中国Exp杂志杂志》2005年3月,32 (3):202 - 9。

PubMed ID

15743404 (在PubMed

]

文摘

1。血管阻力和敏感怀孕期间循环加压和血管收缩剂物质钝化。这主要是由于增加生产endothelium-derived介质。本研究的目的是确定是否怀孕的变化的相对参与一氧化氮(NO)和前列腺素(PG)调制的收缩反应5 -羟色胺(5 -)在两个解剖distint段鼠主动脉。2。得到了完整的量效曲线5 -在孤立的环胸和腹部的一部分从怀孕和没有怀孕的大鼠主动脉的存在和缺乏NO合酶(NOS)抑制剂N (G) -nitro-l-arginine甲酯(L-NAME;10 micromol / L)和PG合成抑制剂吲哚美辛(10 micromol / L)。Cyclo-oxygenase (COX) 1、COX - 2和内皮(e)号在同一组织蛋白表达测定免疫印迹。3所示。怀孕的影响突出的腹部与胸主动脉相比。 In addition, the relative participation of the NO and PG pathways seems to be changed during pregnancy. Although NO seems to be the mediator mainly responsible for the effect of pregnancy in the thoracic aorta, our results suggest a complex interaction between NO and PG in the abdominal aorta. Indomethacin significantly reduced the contractile response of both segments of the aorta, whereas expression of COX-1, COX-2 and eNOS were increased only in the abdominal segment of pregnant animals. 4. These results show that the effect of pregnancy is not homogeneous along the aorta. There seems to be a mutual interaction between PG and NO in the abdominal, but not in the thoracic, aorta from pregnant rats: the role of NO becomes evident in the absence of vasodilatory PG, whereas the participation of the latter increases in the absence of NO working as a compensatory mechanism.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
吲哚美辛	前列腺素合成酶1 G / H	蛋白质	人类	未知的	抑制剂	细节