长春瑞滨(Navelbine)和紫杉醇(Taxol)治疗难治性乳腺癌和肺癌的初步研究。

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张怡，Garrow GC

长春瑞滨(Navelbine)和紫杉醇(Taxol)治疗难治性乳腺癌和肺癌的初步研究。

研讨会1995年4月22日(增刊2 5):66-70;讨论70 - 1。

PubMed ID

7740336 (PubMed视图

]

摘要

Vinorelbine (Navelbine;Burroughs Wellcome Co, Re必威国际appsearch Triangle Park, NC;Pierre Fabre Medicament，巴黎，法国)和紫杉醇(紫杉醇;Bristol-Myers Oncology, Princeton, NJ)作为单药治疗在乳腺癌和肺癌中表现出良好的活性。同时给予长春瑞滨和紫杉醇在体外实现对MCF-7和MDA-MB-231乳腺癌细胞的协同细胞毒性。由于这些药物与微管蛋白上不同的位点结合，并以相反的方式影响微管，因此对一线化疗难治的转移性乳腺癌或肺癌患者进行了一项vinorelbine和紫杉醇联合应用的初步研究。进入标准包括可测量的疾病，Karnofsky性能状态bb0或= 70，充足的骨髓储备，充足的肝肾功能，无中枢神经系统转移。7名患者参加了这项研究(1名乳腺癌患者，6名肺癌患者;三男四女，年龄从39岁到79岁不等)。前3例患者在给予长春瑞滨后第1天、第8天静脉给予长春瑞滨25 mg/m2，持续5 ~ 10分钟，第1天静脉给予紫杉醇90 mg/m2，持续3小时。 Premedication prior to paclitaxel consisted of dexamethasone, cimetidine, and diphenhydramine. The subsequent four patients enrolled in the study received the identical dose of vinorelbine, but the paclitaxel dose was increased to 175 mg/m2 in the same sequence. Patients received granulocyte colony-stimulating factor 5 micrograms/kg subcutaneously from days 3 to 17 (except day 8) or until the absolute granulocyte count was 10,000/microL or higher. Preliminary results showed that one of the first three patients developed grade 4 neutropenia and grade 5 infection. In the subsequent four patients, there were two grade 3 and two grade 4 cases of neutropenia; leukopenic fever or infection did not occur. Two patients required red blood cell transfusions. Two patients developed grade 1 and one patient developed grade 2 peripheral neuropathy. Myalgia and fatigue were common but self-limited. The one patient with breast cancer had a partial response; no response was noted in the lung cancer patients.

引用这篇文章的药物银行数据

药物靶点

药物	目标	种类	生物	药理作用	行动
Vinorelbine	微管蛋白链	蛋白质	人类	是的	拮抗剂 抑制剂	细节