单剂药物动力学和生物利用度的鼻内hydromorphone盐酸在健康志愿者。

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Coda英航,鲁迪AC,阿切尔SM, Wermeling DP

单剂药物动力学和生物利用度的鼻内hydromorphone盐酸在健康志愿者。

7月Anesth。2003; 97(1): 117 - 23,表的内容。

PubMed ID

12818953 (在PubMed

]

文摘

我们评估药物动力学和绝对生物利用度的单剂量盐酸hydromorphone经过政府的1.0和2.0毫克的鼻内(中)和2.0毫克的IV hydromorphone盐酸盐。非盲、随机、三方交叉研究是在24日进行的健康志愿者(13个男性和11个女性)。在剂量交付0.1毫升metered-dose喷洒进一个或两个鼻孔1.0和2.0毫克剂量,分别。血液样本被连续地从0到16 h后每个剂量。等离子体hydromorphone浓度测定液相色谱- spectrometry-mass谱。Noncompartmental分析被用来估计药代动力学变量。意味着hydromorphone生物利用度和百分比52.4%的变异系数(22.7)和57.5%(18.6)1.0 - 2.0毫克剂量后,分别。中位数时间最大浓度剂量20到25分钟。不良事件包括嗜睡和头晕的所有航线管理在剂量后,胃口不好。剂量比例为1.0 - 2.0毫克剂量观察。 IN hydromorphone hydrochloride met the minimum requirements for safety and demonstrated rapid nasal drug absorption and clinically relevant bioavailability. Results support further development of this novel hydromorphone hydrochloride nasal spray. IMPLICATIONS: Pharmacokinetics and bioavailability were determined for two doses of intranasal hydromorphone in healthy volunteers. Rapid, reliable absorption, and predictable pharmacokinetics support the investigation of hydromorphone hydrochloride nasal spray as a therapeutic alternative to oral and IM administration.

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药物

右旋丙氧芬